A convenient method for the synthesis of (prop-2-ynyloxy)benzene derivatives via reaction with propargyl bromide, their optimization, scope and biological evaluation

• Main Authors: Batool, Tannaza, Rasool, Nasir, Gull, Yasmeen, Noreen, Mnaza, Nasim, Faiz-ul-Hassan, Yaqoob, Asma, Zubair, Muhammad, Rana, Usman Ali, Khan, Salah Ud-Din, Zia-Ul-Haq, Muhammad, Jaafar, Hawa Z. E.
• Format: Article
• Language: English
• Published: Public Library of Science 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/36149/1/A%20convenient%20method%20for%20the%20synthesis%20of.pdf; http://psasir.upm.edu.my/id/eprint/36149/; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115457

A highly convenient method has been developed for the synthesis of (prop-2-ynyloxy) benzene and its derivatives. Differently substituted phenol and aniline derivatives were allowed to react with propargyl bromide in the presence of K2CO3 base and acetone as solvent. The compounds were synthesized in...