A bismuth diethyldithiocarbamate compound promotes apoptosis in HepG2 carcinoma, cell cycle arrest and inhibits cell invasion through modulation of the NF-κB activation pathway

• Main Authors: Abang Ishak, Dayang Hazwani, Ooi, Kah Kooi, Ang, Kok Pian, Md. Akim, Abdah, Cheah, Yoke Kqueen, Nordin, Norshariza, Abdul Halim, Siti Nadiah, Seng, Hoi Ling, Tiekink, Edward R. T.
• Format: Article
• Language: English
• Published: Elsevier 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/36121/1/A%20bismuth%20diethyldithiocarbamate%20compound%20promotes%20apoptosis%20in%20HepG2%20carcinoma.pdf; http://psasir.upm.edu.my/id/eprint/36121/

The compound with R = CH2CH3 in Bi(S2CNR2)3 (1) is highly cytotoxic against a range of human carcinoma, whereas that with R = CH2CH2OH (2) is considerably less so. Both 1 and 2 induce apoptosis in HepG2 cells with some evidence for necrosis induced by 2. Based on DNA fragmentation, caspase activitie...