Cover Image

Synthesis and antibacterial study of aaptamine derivatives

Aaptamine is a bioactive marine alkaloid containing a unique of 1H-benzo[de][1,6]naphthyridine skeleton. Aaptamine was isolated from marine sponge, Aaptos aaptos and was proposed as starting material for semi-synthetic modifications. A series of aaptamine derivatives were synthesized which consisted...

Full description

Saved in:
Bibliographic Details
Main Authors: Abdul Rashid, Fatin Nur Ain, Asari, Asnuzilawati, Mohamad, Habsah, Mohd Nor, Siti Mariam
Format: Article
Published: Chemic Publishing Company 2014
Online Access:http://psasir.upm.edu.my/id/eprint/35563/
http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=26_21_43
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.35563
record_format eprints
spelling my.upm.eprints.355632016-01-14T05:06:40Z http://psasir.upm.edu.my/id/eprint/35563/ Synthesis and antibacterial study of aaptamine derivatives Abdul Rashid, Fatin Nur Ain Asari, Asnuzilawati Mohamad, Habsah Mohd Nor, Siti Mariam Aaptamine is a bioactive marine alkaloid containing a unique of 1H-benzo[de][1,6]naphthyridine skeleton. Aaptamine was isolated from marine sponge, Aaptos aaptos and was proposed as starting material for semi-synthetic modifications. A series of aaptamine derivatives were synthesized which consisted of 1,4-dialkyl (2-7), 4-alkyl (8-10) and 9-O-butyryl-1,4-dialkyl (11-16) aaptamine derivatives. Each derivative was characterized by FT-IR, UV-visible, NMR and MS. The synthesized compounds were evaluated for their antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Bacillus cereus, Staphylococcus aureus and Micrococcus sp. bacterial strains using the disc-diffusion method. Some of the derivatives showed potent antibacterial activity against certain bacterial strains. - See more at: http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=26_21_43#sthash.Cij7XzYA.dpuf Chemic Publishing Company 2014 Article PeerReviewed Abdul Rashid, Fatin Nur Ain and Asari, Asnuzilawati and Mohamad, Habsah and Mohd Nor, Siti Mariam (2014) Synthesis and antibacterial study of aaptamine derivatives. Asian Journal of Chemistry, 26 (20). pp. 6903-6907. ISSN 0970-7077 http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=26_21_43 10.14233/ajchem.2014.17377
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Aaptamine is a bioactive marine alkaloid containing a unique of 1H-benzo[de][1,6]naphthyridine skeleton. Aaptamine was isolated from marine sponge, Aaptos aaptos and was proposed as starting material for semi-synthetic modifications. A series of aaptamine derivatives were synthesized which consisted of 1,4-dialkyl (2-7), 4-alkyl (8-10) and 9-O-butyryl-1,4-dialkyl (11-16) aaptamine derivatives. Each derivative was characterized by FT-IR, UV-visible, NMR and MS. The synthesized compounds were evaluated for their antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Bacillus cereus, Staphylococcus aureus and Micrococcus sp. bacterial strains using the disc-diffusion method. Some of the derivatives showed potent antibacterial activity against certain bacterial strains. - See more at: http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=26_21_43#sthash.Cij7XzYA.dpuf
format Article
author Abdul Rashid, Fatin Nur Ain
Asari, Asnuzilawati
Mohamad, Habsah
Mohd Nor, Siti Mariam
spellingShingle Abdul Rashid, Fatin Nur Ain
Asari, Asnuzilawati
Mohamad, Habsah
Mohd Nor, Siti Mariam
Synthesis and antibacterial study of aaptamine derivatives
author_facet Abdul Rashid, Fatin Nur Ain
Asari, Asnuzilawati
Mohamad, Habsah
Mohd Nor, Siti Mariam
author_sort Abdul Rashid, Fatin Nur Ain
title Synthesis and antibacterial study of aaptamine derivatives
title_short Synthesis and antibacterial study of aaptamine derivatives
title_full Synthesis and antibacterial study of aaptamine derivatives
title_fullStr Synthesis and antibacterial study of aaptamine derivatives
title_full_unstemmed Synthesis and antibacterial study of aaptamine derivatives
title_sort synthesis and antibacterial study of aaptamine derivatives
publisher Chemic Publishing Company
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/35563/
http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=26_21_43
_version_ 1643831490920841216
score 13.212271

Similar Items