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Signal Transducer and Activator of Transcription 3 - a promising target in colitis-associated cancer

Colorectal cancer (CRC) is the third most common malignancy and fourth most common cause of cancer mortality worldwide. Untreated chronic inflammation in the intestine ranks among the top three high-risk conditions for colitis-associated colorectal cancer (CAC). Signal Transducer and Activator of Tr...

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Main Authors: Pandurangan, Ashok Kumar, Mohd Esa, Norhaizan
Format: Article
Published: Asian Pacific Education Press Ltd. 2014
Online Access:http://psasir.upm.edu.my/id/eprint/35368/
http://www.apocpcontrol.org/page/apjcp_issues_view.php?sid=Entrez:PubMed&id=pmid:24568457&key=2014.15.2.551
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spelling my.upm.eprints.353682016-01-05T06:52:09Z http://psasir.upm.edu.my/id/eprint/35368/ Signal Transducer and Activator of Transcription 3 - a promising target in colitis-associated cancer Pandurangan, Ashok Kumar Mohd Esa, Norhaizan Colorectal cancer (CRC) is the third most common malignancy and fourth most common cause of cancer mortality worldwide. Untreated chronic inflammation in the intestine ranks among the top three high-risk conditions for colitis-associated colorectal cancer (CAC). Signal Transducer and Activator of Transcription 3(STAT3) protein is a member of the STAT family of transcription factors often deregulated in CRC. In this review, we try to emphasize the critical role of STAT3 in CAC as well as the crosstalk of STAT3 with inflammatory cytokines, nuclear factor (NF)-κB, PI3K/Akt, Mammalian Target of Rapamycin (mTOR), Notch, Wnt/β-catenin and microRNA (MiR) pathways. STAT3 is considered as a primary drug target to treat CAC in humans and rodents. Also we updated the findings for inhibitors of STAT3 with regard to effeects on tumorigenesis. This review will hopefully provide insights on the use of STAT3 as a therapeutic target in CAC. Asian Pacific Education Press Ltd. 2014 Article NonPeerReviewed Pandurangan, Ashok Kumar and Mohd Esa, Norhaizan (2014) Signal Transducer and Activator of Transcription 3 - a promising target in colitis-associated cancer. Asian Pacific Journal of Cancer Prevention, 15 (2). pp. 551-560. ISSN 1513-7368 http://www.apocpcontrol.org/page/apjcp_issues_view.php?sid=Entrez:PubMed&id=pmid:24568457&key=2014.15.2.551 10.7314/APJCP.2014.15.2.551
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Colorectal cancer (CRC) is the third most common malignancy and fourth most common cause of cancer mortality worldwide. Untreated chronic inflammation in the intestine ranks among the top three high-risk conditions for colitis-associated colorectal cancer (CAC). Signal Transducer and Activator of Transcription 3(STAT3) protein is a member of the STAT family of transcription factors often deregulated in CRC. In this review, we try to emphasize the critical role of STAT3 in CAC as well as the crosstalk of STAT3 with inflammatory cytokines, nuclear factor (NF)-κB, PI3K/Akt, Mammalian Target of Rapamycin (mTOR), Notch, Wnt/β-catenin and microRNA (MiR) pathways. STAT3 is considered as a primary drug target to treat CAC in humans and rodents. Also we updated the findings for inhibitors of STAT3 with regard to effeects on tumorigenesis. This review will hopefully provide insights on the use of STAT3 as a therapeutic target in CAC.
format Article
author Pandurangan, Ashok Kumar
Mohd Esa, Norhaizan
spellingShingle Pandurangan, Ashok Kumar
Mohd Esa, Norhaizan
Signal Transducer and Activator of Transcription 3 - a promising target in colitis-associated cancer
author_facet Pandurangan, Ashok Kumar
Mohd Esa, Norhaizan
author_sort Pandurangan, Ashok Kumar
title Signal Transducer and Activator of Transcription 3 - a promising target in colitis-associated cancer
title_short Signal Transducer and Activator of Transcription 3 - a promising target in colitis-associated cancer
title_full Signal Transducer and Activator of Transcription 3 - a promising target in colitis-associated cancer
title_fullStr Signal Transducer and Activator of Transcription 3 - a promising target in colitis-associated cancer
title_full_unstemmed Signal Transducer and Activator of Transcription 3 - a promising target in colitis-associated cancer
title_sort signal transducer and activator of transcription 3 - a promising target in colitis-associated cancer
publisher Asian Pacific Education Press Ltd.
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/35368/
http://www.apocpcontrol.org/page/apjcp_issues_view.php?sid=Entrez:PubMed&id=pmid:24568457&key=2014.15.2.551
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score 13.211869

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