Prophylactic effect of herbal-marine compound (HESA-A) on influenza A virus infectivity
BACKGROUND: Influenza virus is still a severe respiratory disease affecting human and other species. As conventional drugs are not recommended for long time because of side effects and drug resistance occurrence, traditional medication has been focused as alternative remedy. HESA-A is a natural com...
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Online Access: | http://psasir.upm.edu.my/id/eprint/35088/ http://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-14-131 |
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my.upm.eprints.350882015-12-30T04:37:19Z http://psasir.upm.edu.my/id/eprint/35088/ Prophylactic effect of herbal-marine compound (HESA-A) on influenza A virus infectivity Mehrbod, Parvaneh Ideris, Aini Omar, Abdul Rahman Bejo, Mohd Hair BACKGROUND: Influenza virus is still a severe respiratory disease affecting human and other species. As conventional drugs are not recommended for long time because of side effects and drug resistance occurrence, traditional medication has been focused as alternative remedy. HESA-A is a natural compound from herbal-marine origin. Previous studies have reported the therapeutic properties of HESA-A on psoriasis vulgaris and different types of cancers and we also showed its anti-inflammatory effects against influenza A infection. METHODS: This study was designed to investigate the potential properties of HESA-A as prophylaxis or treatment. To investigate the prophylaxis or treatment activities of HESA-A, Madin-Darby Canine Kidney (MDCK) cells were exposed to HESA-A and influenza A virus in different manners of exposure and different time intervals. The results were evaluated by MTT and HA assays. RESULTS: It was found that HESA-A is much more effective against influenza cytopathic effects when it is applied for prophylaxis and also in concurrent treatment (p ≤ 0.05) but not in post-infection treatment (p ≥ 0.05). CONCLUSION: In conclusion, HESA-A is significantly effective against influenza replication in prophylaxis application affecting the virus penetration/adsorption to the cell without any toxic effect on the cell viability. BioMed Central 2014 Article PeerReviewed Mehrbod, Parvaneh and Ideris, Aini and Omar, Abdul Rahman and Bejo, Mohd Hair (2014) Prophylactic effect of herbal-marine compound (HESA-A) on influenza A virus infectivity. BMC Complementary and Alternative Medicine, 14. art. no. 131. pp. 1-4. ISSN 1472-6882 http://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-14-131 1186/1472-6882-14-131 |
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BACKGROUND:
Influenza virus is still a severe respiratory disease affecting human and other species. As conventional drugs are not recommended for long time because of side effects and drug resistance occurrence, traditional medication has been focused as alternative remedy. HESA-A is a natural compound from herbal-marine origin. Previous studies have reported the therapeutic properties of HESA-A on psoriasis vulgaris and different types of cancers and we also showed its anti-inflammatory effects against influenza A infection.
METHODS:
This study was designed to investigate the potential properties of HESA-A as prophylaxis or treatment. To investigate the prophylaxis or treatment activities of HESA-A, Madin-Darby Canine Kidney (MDCK) cells were exposed to HESA-A and influenza A virus in different manners of exposure and different time intervals. The results were evaluated by MTT and HA assays.
RESULTS:
It was found that HESA-A is much more effective against influenza cytopathic effects when it is applied for prophylaxis and also in concurrent treatment (p ≤ 0.05) but not in post-infection treatment (p ≥ 0.05).
CONCLUSION:
In conclusion, HESA-A is significantly effective against influenza replication in prophylaxis application affecting the virus penetration/adsorption to the cell without any toxic effect on the cell viability. |
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Article |
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Mehrbod, Parvaneh Ideris, Aini Omar, Abdul Rahman Bejo, Mohd Hair |
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Mehrbod, Parvaneh Ideris, Aini Omar, Abdul Rahman Bejo, Mohd Hair Prophylactic effect of herbal-marine compound (HESA-A) on influenza A virus infectivity |
author_facet |
Mehrbod, Parvaneh Ideris, Aini Omar, Abdul Rahman Bejo, Mohd Hair |
author_sort |
Mehrbod, Parvaneh |
title |
Prophylactic effect of herbal-marine compound (HESA-A) on influenza A virus infectivity |
title_short |
Prophylactic effect of herbal-marine compound (HESA-A) on influenza A virus infectivity |
title_full |
Prophylactic effect of herbal-marine compound (HESA-A) on influenza A virus infectivity |
title_fullStr |
Prophylactic effect of herbal-marine compound (HESA-A) on influenza A virus infectivity |
title_full_unstemmed |
Prophylactic effect of herbal-marine compound (HESA-A) on influenza A virus infectivity |
title_sort |
prophylactic effect of herbal-marine compound (hesa-a) on influenza a virus infectivity |
publisher |
BioMed Central |
publishDate |
2014 |
url |
http://psasir.upm.edu.my/id/eprint/35088/ http://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-14-131 |
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