p53 and p21 mRNA and protein expression in treated synthetic oestrogen in mouse transgenic animal model

• Main Authors: Salleh, Mohd Nazil, Ahmad Mulyadi Lai, Henkie Isahwan, Mustaffa, Mohd Irfan Raimi, Wan Ramli, Wan Khairuzzaman, Ismail, Patimah
• Format: Article
• Language: English
• Published: IDOSI Publications 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/34803/1/p53%20and%20p21%20mRNA%20and%20protein%20expression%20in%20treated%20synthetic%20oestrogen%20in%20mouse%20transgenic%20animal%20model.pdf; http://psasir.upm.edu.my/id/eprint/34803/; http://www.idosi.org/ajcr/ajcr7%282%2914.htm

Studies with Diethylstilbestrol (DES) in humans and rodents have resulted in a spectrum of toxic and carcinogenic effects. Previous findings on gene expression profiles following DES treatment showed that p53, p21 and bax was transcriptionally regulated in this model. In the present studies, we used...