Metabolites from Actinomyces strain H6552 extract inhibit transforming growth factor mediated pulmonary fibrosis

• Main Authors: Koh, Rhun Yian, Lim, Chooi Ling, Ho, Coy Choke, Uhal, Bruce David, Abdullah, Maha, Vidyadaran, Sharmili, Seow, Heng Fong
• Format: Article
• Published: Pharmacotherapy Group, Faculty of Pharmacy, University of Benin 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/34496/; http://www.tjpr.org/vol13_no11/2014_13_11_7.php

Purpose: To evaluate the effects of H6552 extract in inhibiting transforming growth factor (TGF)-mediated pulmonary fibrosis in vitro and in vivo. Methods: Maximum-nontoxic dose (MNTD) of Actinomyces H6552 extract was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphhenyltetrazolium bromide (M...