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Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review

Luteolin, 3’, 4’, 5,7-tetrahydroxyflavone, belongs to a group of naturally occurring compounds called flavonoids that are found widely in the plant kingdom. It possesses many beneficial properties including antioxidant, antiinflammatory, anti-bacterial, anti-diabetic and anti-proliferative actions....

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Main Authors: Pandurangan, Ashok Kumar, Mohd Esa, Norhaizan
Format: Article
Published: Asian Pacific Education Press Ltd. 2014
Online Access:http://psasir.upm.edu.my/id/eprint/34405/
http://www.apocpcontrol.org/page/apjcp_issues_view.php?sid=Entrez:PubMed&id=pmid:25081655&key=2014.15.14.5501
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spelling my.upm.eprints.344052015-12-15T01:05:00Z http://psasir.upm.edu.my/id/eprint/34405/ Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review Pandurangan, Ashok Kumar Mohd Esa, Norhaizan Luteolin, 3’, 4’, 5,7-tetrahydroxyflavone, belongs to a group of naturally occurring compounds called flavonoids that are found widely in the plant kingdom. It possesses many beneficial properties including antioxidant, antiinflammatory, anti-bacterial, anti-diabetic and anti-proliferative actions. Colorectal cancer (CRC) is a leading cause of cancer related deaths worldwide. Many signaling pathways are deregulated during the progression of colon cancer. In this review we aimed to analyze the protection offered by luteolin on colon cancer. During colon cancer genesis, luteolin known to reduce oxidative stress thereby protects the cell to undergo damage in vivo. Wnt/β-catenin signaling, deregulated during neoplastic development, is modified by luteolin. Hence, luteolin can be considered as a potential drug to treat CRC. Asian Pacific Education Press Ltd. 2014 Article NonPeerReviewed Pandurangan, Ashok Kumar and Mohd Esa, Norhaizan (2014) Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review. Asian Pacific Journal of Cancer Prevention, 15 (14). pp. 5501-5508. ISSN 1513-7368 http://www.apocpcontrol.org/page/apjcp_issues_view.php?sid=Entrez:PubMed&id=pmid:25081655&key=2014.15.14.5501 10.7314/APJCP.2014.15.14.5501
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Luteolin, 3’, 4’, 5,7-tetrahydroxyflavone, belongs to a group of naturally occurring compounds called flavonoids that are found widely in the plant kingdom. It possesses many beneficial properties including antioxidant, antiinflammatory, anti-bacterial, anti-diabetic and anti-proliferative actions. Colorectal cancer (CRC) is a leading cause of cancer related deaths worldwide. Many signaling pathways are deregulated during the progression of colon cancer. In this review we aimed to analyze the protection offered by luteolin on colon cancer. During colon cancer genesis, luteolin known to reduce oxidative stress thereby protects the cell to undergo damage in vivo. Wnt/β-catenin signaling, deregulated during neoplastic development, is modified by luteolin. Hence, luteolin can be considered as a potential drug to treat CRC.
format Article
author Pandurangan, Ashok Kumar
Mohd Esa, Norhaizan
spellingShingle Pandurangan, Ashok Kumar
Mohd Esa, Norhaizan
Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review
author_facet Pandurangan, Ashok Kumar
Mohd Esa, Norhaizan
author_sort Pandurangan, Ashok Kumar
title Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review
title_short Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review
title_full Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review
title_fullStr Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review
title_full_unstemmed Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review
title_sort luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review
publisher Asian Pacific Education Press Ltd.
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/34405/
http://www.apocpcontrol.org/page/apjcp_issues_view.php?sid=Entrez:PubMed&id=pmid:25081655&key=2014.15.14.5501
_version_ 1643831144366473216
score 13.160551

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