In vitro ultrastructural changes of MCF-7 for metastasise bone cancer and induction of apoptosis via mitochondrial cytochrome C released by CaCO3/Dox nanocrystals

• Main Authors: Kamba, Abdullahi Shafiu, Ismail, Maznah, Tengku Ibrahim, Tengku Azmi, Abu Bakar @ Zakaria, Md Zuki, Gusau, Lawal Hassan
• Format: Article
• Language: English
• Published: Hindawi Publishing Corporation 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/34153/1/In%20Vitro%20Ultrastructural%20Changes%20of%20MCF-7%20for%20Metastasise.pdf; http://psasir.upm.edu.my/id/eprint/34153/; http://www.hindawi.com/journals/bmri/2014/391869/abs/

Bones are the most frequent site for breast cancer cells to settle and spread (metastasise); bone metastasis is considered to have a substantial impact on the quality of patients with common cancers. However, majority of breast cancers develop insensitivity to conventional chemotherapy which provide...