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Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components

The present invention provides recombinant plasmids comprising MrNV capsid gene and optionally also myc gene carrying immunogenic component (such as ‘a’ determinant of HBV and M2e of influenza virus genes) at the 3’ terminus of the MrNV capsid gene and/or 5’ terminus of myc and hexa-His coding regio...

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Main Authors: Tan, Wen Siang, Ho, Kok Lian, Yong, Chean Yeah, Goh, Zee Hong, Omar, Abdul Rahman, Yeap, Swee Keong
Format: Patent
Published: 2014
Online Access:http://psasir.upm.edu.my/id/eprint/33963/
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spelling my.upm.eprints.339632015-04-24T13:38:54Z http://psasir.upm.edu.my/id/eprint/33963/ Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components Tan, Wen Siang Ho, Kok Lian Yong, Chean Yeah Goh, Zee Hong Omar, Abdul Rahman Yeap, Swee Keong The present invention provides recombinant plasmids comprising MrNV capsid gene and optionally also myc gene carrying immunogenic component (such as ‘a’ determinant of HBV and M2e of influenza virus genes) at the 3’ terminus of the MrNV capsid gene and/or 5’ terminus of myc and hexa-His coding region. The present invention further provides spherical epitope-displaying virus-like particles (VLPs) comprising the MrNV capsid protein and one or more immunogenic components, such as ‘a’ determinant of HBV and M2e of influenza virus. The particles may contain one or more copies of each epitope. The invention further provides a method of producing such VLPs, and uses of such VLPs. 2014-09-09 Patent NonPeerReviewed Tan Wen Siang (2014) Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components. PI2014702540.
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description The present invention provides recombinant plasmids comprising MrNV capsid gene and optionally also myc gene carrying immunogenic component (such as ‘a’ determinant of HBV and M2e of influenza virus genes) at the 3’ terminus of the MrNV capsid gene and/or 5’ terminus of myc and hexa-His coding region. The present invention further provides spherical epitope-displaying virus-like particles (VLPs) comprising the MrNV capsid protein and one or more immunogenic components, such as ‘a’ determinant of HBV and M2e of influenza virus. The particles may contain one or more copies of each epitope. The invention further provides a method of producing such VLPs, and uses of such VLPs.
format Patent
author Tan, Wen Siang
Ho, Kok Lian
Yong, Chean Yeah
Goh, Zee Hong
Omar, Abdul Rahman
Yeap, Swee Keong
spellingShingle Tan, Wen Siang
Ho, Kok Lian
Yong, Chean Yeah
Goh, Zee Hong
Omar, Abdul Rahman
Yeap, Swee Keong
Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components
author_facet Tan, Wen Siang
Ho, Kok Lian
Yong, Chean Yeah
Goh, Zee Hong
Omar, Abdul Rahman
Yeap, Swee Keong
author_sort Tan, Wen Siang
title Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components
title_short Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components
title_full Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components
title_fullStr Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components
title_full_unstemmed Virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components
title_sort virus-like particles of macrobrachium rosenbergii nodavirus capsid as a carrier for immunogenic components
publishDate 2014
url http://psasir.upm.edu.my/id/eprint/33963/
_version_ 1643831018252140544
score 13.211869

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