A radioactive silica-coated gold nanoparticle and a method for producing thereof

• Main Authors: Hussain, Siti Aslina, Mohd Yunos, Mohd Amirul Syafiq
• Format: Patent
• Published: 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/33737/

The present invention relates to a radioactive tracer characterized by a silica-coated gold nanoparticle comprising 0.1 to 1 wt% gold, having a diameter in a range of 70 to 200 nanometers and radioactivity in a range of 55.5 to 129.5 MBq. The present invention also provides a method for producing a radioactive tracer comprising a silica-coated gold nanoparticle, characterized by the steps of heating the colloidal gold nanoparticle solution; mixing the colloidal nanoparticle solution with an alcohol to form a mixture; adding an ammonia solution, followed by a silica compound into the mixture to form the silica-coated gold nanoparticle; washing and centrifuging the silica-coated gold nanoparticle, thereby separating the silica-coated gold nanoparticle from unwanted solution; calcining the silica-coated gold nanoparticle for producing silica-coated gold nanoparticle powder; subjecting the silica-coated gold nanoparticle powder to neutron irradiation.