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Antibacterial, cytotoxic studies and characterization of some newly synthesized symmetrical N 3, N 3 ′ -bis(disubstituted)isophthalyl- bis(thioureas) and their Cu(II) and Ni(II) complexes

A series of some novel ,-bis(disubstituted)isophthalyl-bis(thioureas) compounds with general formula [C6H4 {CONHCSNHR}2], where R = 2-ClC6H4S (L1), 3,5-(Cl)2C6H3 (L2), 2,4-(Cl)2C6H3 (L3), 2,5-(Cl)2C6H3 (L4), and 2-NH2C6H4 (L5), and their Cu(II) and Ni(II) complexes (C1–C10) have been synthesized. Th...

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Main Authors: Jamil, Muhammad, Zubair, Muhammad, Farid, Muhammad Asim, Rashid, Umer, Rasool, Nasir, Islam, Saiful
Format: Article
Language:English
English
Published: Hindawi Publishing Corporation 2013
Online Access:http://psasir.upm.edu.my/id/eprint/30814/1/Antibacterial.pdf
http://psasir.upm.edu.my/id/eprint/30814/
http://www.hindawi.com/journals/jchem/2013/789743/
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spelling my.upm.eprints.308142015-10-05T01:29:00Z http://psasir.upm.edu.my/id/eprint/30814/ Antibacterial, cytotoxic studies and characterization of some newly synthesized symmetrical N 3, N 3 ′ -bis(disubstituted)isophthalyl- bis(thioureas) and their Cu(II) and Ni(II) complexes Jamil, Muhammad Zubair, Muhammad Farid, Muhammad Asim Rashid, Umer Rasool, Nasir Islam, Saiful A series of some novel ,-bis(disubstituted)isophthalyl-bis(thioureas) compounds with general formula [C6H4 {CONHCSNHR}2], where R = 2-ClC6H4S (L1), 3,5-(Cl)2C6H3 (L2), 2,4-(Cl)2C6H3 (L3), 2,5-(Cl)2C6H3 (L4), and 2-NH2C6H4 (L5), and their Cu(II) and Ni(II) complexes (C1–C10) have been synthesized. These compounds (L1–L5) and their metal(II) complexes (C1–C10) have been characterized by elemental analysis, infrared spectroscopy, 1H NMR and 13C NMR spectroscopy, magnetic moments, and electronic spectral measurements. The ligands are coordinated to metal atom in a bidentate pattern producing a neutral complex of the type [ML]2. These compounds (L1–L5) and their metal(II) complexes (C1–C10) were also screened for their antibacterial and cytotoxic activities. Hindawi Publishing Corporation 2013-09-09 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/30814/1/Antibacterial.pdf Jamil, Muhammad and Zubair, Muhammad and Farid, Muhammad Asim and Rashid, Umer and Rasool, Nasir and Islam, Saiful (2013) Antibacterial, cytotoxic studies and characterization of some newly synthesized symmetrical N 3, N 3 ′ -bis(disubstituted)isophthalyl- bis(thioureas) and their Cu(II) and Ni(II) complexes. Journal of Chemistry, 2013. art. no. 789743. pp. 1-8. ISSN 2090-9063; ESSN: 2090-9071 http://www.hindawi.com/journals/jchem/2013/789743/ 10.1155/2013/789743 English
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
English
description A series of some novel ,-bis(disubstituted)isophthalyl-bis(thioureas) compounds with general formula [C6H4 {CONHCSNHR}2], where R = 2-ClC6H4S (L1), 3,5-(Cl)2C6H3 (L2), 2,4-(Cl)2C6H3 (L3), 2,5-(Cl)2C6H3 (L4), and 2-NH2C6H4 (L5), and their Cu(II) and Ni(II) complexes (C1–C10) have been synthesized. These compounds (L1–L5) and their metal(II) complexes (C1–C10) have been characterized by elemental analysis, infrared spectroscopy, 1H NMR and 13C NMR spectroscopy, magnetic moments, and electronic spectral measurements. The ligands are coordinated to metal atom in a bidentate pattern producing a neutral complex of the type [ML]2. These compounds (L1–L5) and their metal(II) complexes (C1–C10) were also screened for their antibacterial and cytotoxic activities.
format Article
author Jamil, Muhammad
Zubair, Muhammad
Farid, Muhammad Asim
Rashid, Umer
Rasool, Nasir
Islam, Saiful
spellingShingle Jamil, Muhammad
Zubair, Muhammad
Farid, Muhammad Asim
Rashid, Umer
Rasool, Nasir
Islam, Saiful
Antibacterial, cytotoxic studies and characterization of some newly synthesized symmetrical N 3, N 3 ′ -bis(disubstituted)isophthalyl- bis(thioureas) and their Cu(II) and Ni(II) complexes
author_facet Jamil, Muhammad
Zubair, Muhammad
Farid, Muhammad Asim
Rashid, Umer
Rasool, Nasir
Islam, Saiful
author_sort Jamil, Muhammad
title Antibacterial, cytotoxic studies and characterization of some newly synthesized symmetrical N 3, N 3 ′ -bis(disubstituted)isophthalyl- bis(thioureas) and their Cu(II) and Ni(II) complexes
title_short Antibacterial, cytotoxic studies and characterization of some newly synthesized symmetrical N 3, N 3 ′ -bis(disubstituted)isophthalyl- bis(thioureas) and their Cu(II) and Ni(II) complexes
title_full Antibacterial, cytotoxic studies and characterization of some newly synthesized symmetrical N 3, N 3 ′ -bis(disubstituted)isophthalyl- bis(thioureas) and their Cu(II) and Ni(II) complexes
title_fullStr Antibacterial, cytotoxic studies and characterization of some newly synthesized symmetrical N 3, N 3 ′ -bis(disubstituted)isophthalyl- bis(thioureas) and their Cu(II) and Ni(II) complexes
title_full_unstemmed Antibacterial, cytotoxic studies and characterization of some newly synthesized symmetrical N 3, N 3 ′ -bis(disubstituted)isophthalyl- bis(thioureas) and their Cu(II) and Ni(II) complexes
title_sort antibacterial, cytotoxic studies and characterization of some newly synthesized symmetrical n 3, n 3 ′ -bis(disubstituted)isophthalyl- bis(thioureas) and their cu(ii) and ni(ii) complexes
publisher Hindawi Publishing Corporation
publishDate 2013
url http://psasir.upm.edu.my/id/eprint/30814/1/Antibacterial.pdf
http://psasir.upm.edu.my/id/eprint/30814/
http://www.hindawi.com/journals/jchem/2013/789743/
_version_ 1643830171787067392
score 13.160551

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