Synthesis of some novel α-cyanoketene-n, s-acetals derived from secondary aliphatic amines and their use in pyrazole synthesis

• Main Authors: Al-Adiwish, Wedad M., Mohamed Tahir, Mohamed Ibrahim, Wan Ahmad, Wan Yaakob
• Format: Article
• Language: English; English
• Published: Taylor & Francis 2013
• Online Access: http://psasir.upm.edu.my/id/eprint/30236/1/Synthesis%20of%20some%20novel%20%CE%B1.pdf; http://psasir.upm.edu.my/id/eprint/30236/

New α-cyanoketene-N,S-acetals 2(a–g) and β-dialkylamine-α-cyanoacrylates 3(g–i) were synthesized in good to excellent yields by the reaction of ethyl 2-cyano-3,3-bis(methylthio)acrylate 1 with secondary aliphatic amines (i.e., N-methylalkyl- and N-ethylalkylamines), and pyrrolidine, in the presence...