Vasorelaxant activity of indole alkaloids from Tabernaemontana dichotoma.

• Main Authors: Zaima, Kazumasa, Koga, Ikumi, Iwasawa, Nobuhide, Hosoya, Takahiro, Hirasawa, Yusuke, Kaneda, Toshio, Ismail, Intan Safinar, Lajis, Nordin, Morita, Hiroshi
• Format: Article
• Language: English
• Published: Springer Verlag 2013
• Online Access: http://psasir.upm.edu.my/id/eprint/29981/1/Vasorelaxant%20activity%20of%20indole%20alkaloids%20from%20Tabernaemontana%20dichotoma.pdf; http://psasir.upm.edu.my/id/eprint/29981/

The aim of this study was to search for bioactive natural products from medicinal plants targeting vasorelaxant activity and we found the methanol extract from bark of Tabernaemontana dichotoma showed vasorelaxant activity on rat aorta. We isolated eight indole alkaloids including 10-methoxyalstoner...