The combined influence of substrate elasticity and surface-grafted molecules on the exvivo expansion of hematopoietic stem and progenitor cells

• Main Authors: Kumar, Suresh, Hsiao, Jui Hsiang, Ling, Qing Dong, Ida, Dulinska Molak, Chen, Guoping, Chang, Yung, Chang, Yu, Chen, Yung Hung, Chen, Da Chung, Hsu, Shih Tien, Higuchi, Akon
• Format: Article
• Language: English
• Published: Elsevier 2013
• Online Access: http://psasir.upm.edu.my/id/eprint/29796/1/The%20combined%20influence%20of%20substrate%20elasticity%20and%20surface.pdf; http://psasir.upm.edu.my/id/eprint/29796/

Umbilical cord blood (UCB) is an attractive source of hematopoietic stem and progenitor cells (HSPCs) for transplantation. However, the low number of HSPCs from a single UCB donor limits the direct transplantation of UCB to patients. Because little is known about the effects of the physical microenv...