Multidrug resistance protein 2 genetic polymorphism and colorectal cancer recurrence in patients receiving adjuvant FOLFOX-4 chemotherapy

• Main Authors: Mirakhorli, Mojgan, Abdul Rahman, Sabariah, Abdullah, Syahrilnizam, Vakili, Masoud, Rozafzon, Reza, Khoshzaban, Ahad
• Format: Article
• Language: English
• Published: Spandidos Publications 2013
• Online Access: http://psasir.upm.edu.my/id/eprint/29782/1/Multidrug%20resistance%20protein%202%20genetic%20polymorphism%20and%20colorectal%20cancer%20recurrence%20in%20patients%20receiving%20adjuvant%20FOLFOX.docx; http://psasir.upm.edu.my/id/eprint/29782/

Multidrug resistance protein 2 (MRP2), encoded by the ATP-binding cassette C2 (ABCC2) gene, is an efflux pump located on the apical membrane of many polarized cells, which transports conjugate compounds by an ATP-dependent mechanism. The correlation of G1249A ABCC2 polymorphism with the development...