Prevalence of metabolic syndrome in type 2 diabetic patients: a comparative study using WHO, NCEP ATP III, IDF and Harmonized definitions
To determine the prevalence of metabolic syndrome (MetS) in Malaysian type 2 diabetic patients using WHO, NCEP ATP III, IDF and the new Harmonized definitions, and the concordance between these definitions. This study involved 313 patients diagnosed with type 2 diabetes mellitus (T2DM) at two Malays...
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my.upm.eprints.297292015-12-08T02:00:08Z http://psasir.upm.edu.my/id/eprint/29729/ Prevalence of metabolic syndrome in type 2 diabetic patients: a comparative study using WHO, NCEP ATP III, IDF and Harmonized definitions Tan, Mun Chieng Ng, Ooi Chuan Wong, Teck Wee Joseph, Anthony Chan, Yoke Mun Hejar, Abdul Rahman To determine the prevalence of metabolic syndrome (MetS) in Malaysian type 2 diabetic patients using WHO, NCEP ATP III, IDF and the new Harmonized definitions, and the concordance between these definitions. This study involved 313 patients diagnosed with type 2 diabetes mellitus (T2DM) at two Malaysian tertiary hospitals. Socio-demographic data were assessed using a pre-tested interviewer-administered structured questionnaire. Anthropometric measurements were carried out according to standard protocols. Clinical and laboratory characteristics were examined. Kappa (k) statistics were used for the agreement between the four MetS definitions. The overall prevalence rates of MetS (95% CI) were 95.8% (93.6-98.1), 96.1% (94.0-98.3), 84.8% (80.8-88.9) and 97.7% (96.1-99.4) according to the WHO, NCEP ATP III, IDF and the Harmonized definitions, respectively. The Kappa statistics demonstrated a slight to substantial agreement between the definitions (k = 0.179-0.875, p < 0.001), where the WHO criteria revealed the highest concordance with the NCEP ATP III definition (k = 0.875, p < 0.001). The WHO against NCEP ATP III criteria evinced the highest sensitivity (99.66%) whereas Harmonized criteria against all the other three definitions showed the highest specificity (100%) in identifying MetS. In conclusion, the new Harmonized criteria established the highest prevalence of MetS among the four definitions applied. There was a very good concordance between the WHO and NCEP ATP III criteria. The extremely high prevalence of MetS observed in type 2 diabetic patients indicates an impending pandemic of CVD risk in Malaysia. Aggressive treatment of MetS components is required to reduce cardiovascular risk in T2DM. Scientific Research Publishing 2013-10 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29729/1/Prevalence%20of%20metabolic%20syndrome%20in%20type%202%20diabetic%20patients.pdf Tan, Mun Chieng and Ng, Ooi Chuan and Wong, Teck Wee and Joseph, Anthony and Chan, Yoke Mun and Hejar, Abdul Rahman (2013) Prevalence of metabolic syndrome in type 2 diabetic patients: a comparative study using WHO, NCEP ATP III, IDF and Harmonized definitions. Health, 5 (10). pp. 1689-1696. ISSN 1949-4998; ESSN: 1949-5005 http://www.scirp.org/journal/PaperInformation.aspx?PaperID=38005#.VVu_p_mqqko 10.4236/health.2013.510227 |
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To determine the prevalence of metabolic syndrome (MetS) in Malaysian type 2 diabetic patients using WHO, NCEP ATP III, IDF and the new Harmonized definitions, and the concordance between these definitions. This study involved 313 patients diagnosed with type 2 diabetes mellitus (T2DM) at two Malaysian tertiary hospitals. Socio-demographic data were assessed using a pre-tested interviewer-administered structured questionnaire. Anthropometric measurements were carried out according to standard protocols. Clinical and laboratory characteristics were examined. Kappa (k) statistics were used for the agreement between the four MetS definitions. The overall prevalence rates of MetS (95% CI) were 95.8% (93.6-98.1), 96.1% (94.0-98.3), 84.8% (80.8-88.9) and 97.7% (96.1-99.4) according to the WHO, NCEP ATP III, IDF and the Harmonized definitions, respectively. The Kappa statistics demonstrated a slight to substantial agreement between the definitions (k = 0.179-0.875, p < 0.001), where the WHO criteria revealed the highest concordance with the NCEP ATP III definition (k = 0.875, p < 0.001). The WHO against NCEP ATP III criteria evinced the highest sensitivity (99.66%) whereas Harmonized criteria against all the other three definitions showed the highest specificity (100%) in identifying MetS. In conclusion, the new Harmonized criteria established the highest prevalence of MetS among the four definitions applied. There was a very good concordance between the WHO and NCEP ATP III criteria. The extremely high prevalence of MetS observed in type 2 diabetic patients indicates an impending pandemic of CVD risk in Malaysia. Aggressive treatment of MetS components is required to reduce cardiovascular risk in T2DM. |
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Article |
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Tan, Mun Chieng Ng, Ooi Chuan Wong, Teck Wee Joseph, Anthony Chan, Yoke Mun Hejar, Abdul Rahman |
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Tan, Mun Chieng Ng, Ooi Chuan Wong, Teck Wee Joseph, Anthony Chan, Yoke Mun Hejar, Abdul Rahman Prevalence of metabolic syndrome in type 2 diabetic patients: a comparative study using WHO, NCEP ATP III, IDF and Harmonized definitions |
author_facet |
Tan, Mun Chieng Ng, Ooi Chuan Wong, Teck Wee Joseph, Anthony Chan, Yoke Mun Hejar, Abdul Rahman |
author_sort |
Tan, Mun Chieng |
title |
Prevalence of metabolic syndrome in type 2 diabetic patients: a comparative study using WHO, NCEP ATP III, IDF and Harmonized definitions |
title_short |
Prevalence of metabolic syndrome in type 2 diabetic patients: a comparative study using WHO, NCEP ATP III, IDF and Harmonized definitions |
title_full |
Prevalence of metabolic syndrome in type 2 diabetic patients: a comparative study using WHO, NCEP ATP III, IDF and Harmonized definitions |
title_fullStr |
Prevalence of metabolic syndrome in type 2 diabetic patients: a comparative study using WHO, NCEP ATP III, IDF and Harmonized definitions |
title_full_unstemmed |
Prevalence of metabolic syndrome in type 2 diabetic patients: a comparative study using WHO, NCEP ATP III, IDF and Harmonized definitions |
title_sort |
prevalence of metabolic syndrome in type 2 diabetic patients: a comparative study using who, ncep atp iii, idf and harmonized definitions |
publisher |
Scientific Research Publishing |
publishDate |
2013 |
url |
http://psasir.upm.edu.my/id/eprint/29729/1/Prevalence%20of%20metabolic%20syndrome%20in%20type%202%20diabetic%20patients.pdf http://psasir.upm.edu.my/id/eprint/29729/ http://www.scirp.org/journal/PaperInformation.aspx?PaperID=38005#.VVu_p_mqqko |
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13.18916 |