Molecular alterations of Ras-Raf-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt signaling pathways in colorectal cancers from a tertiary hospital at Kuala Lumpur, Malaysia

• Main Authors: Yip, Wai Kien, Choo, Chee Wei, Leong, Vincent Ching Shian, Leong, Pooi Pooi, Jabar, Mohd Faisal, Seow, Heng Fong
• Format: Article
• Language: English
• Published: John Wiley & Sons 2013
• Online Access: http://psasir.upm.edu.my/id/eprint/29699/1/Molecular%20alterations%20of%20Ras-Raf-mitogen-activated%20protein%20kinase%20and%20phosphatidylinositol%203-kinase-Akt%20signaling%20pathways%20in%20colorectal%20cancers%20from%20a%20tertiary%20hospital%20at%20Kuala%20Lumpur%2C%20Malaysia.pdf; http://psasir.upm.edu.my/id/eprint/29699/

Molecular alterations in KRAS, BRAF, PIK3CA, and PTEN have been implicated in designing targeted therapy for colorectal cancer (CRC). The present study aimed to determine the status of these molecular alterations in Malaysian CRCs as such data are not available in the literature. We investigated the...