Effect of methanol extract of Dicranopteris linearis leaves against paracetamol- and carbon tetrachloride (CCl4)-induced liver toxicity in rats
The present study aimed to determine the hepatoprotective activity of methanol extract of Dicranopteris linearis leaves (MEDL) using two models of liver injury in r ats. Rats (n = 6) received 10% DMSO(negative control), 200 mg/kg silymarin (positive control) or MEDL (50, 250, and 500 mg/kg) orally...
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Academic Journals
2013
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Online Access: | http://psasir.upm.edu.my/id/eprint/29680/1/Effect%20of%20methanol%20extract%20of%20Dicranopteris%20linearis%20leaves%20against%20paracetamol.pdf http://psasir.upm.edu.my/id/eprint/29680/ http://www.biomedcentral.com/1472-6882/14/123/abstract |
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my.upm.eprints.296802015-10-07T07:57:16Z http://psasir.upm.edu.my/id/eprint/29680/ Effect of methanol extract of Dicranopteris linearis leaves against paracetamol- and carbon tetrachloride (CCl4)-induced liver toxicity in rats Mamat, Siti Syariah Kamisan, Farah Hidayah Wan Zainulddin, Wan Noraziemah Ismail, Noor Aisyah Yahya, Farhana Din, Siti Shamsahal Zabidi, Zalina Mohtarrudin, Norhafizah Abd. Kadir, Arifah Zakaria, Zainul Amiruddin The present study aimed to determine the hepatoprotective activity of methanol extract of Dicranopteris linearis leaves (MEDL) using two models of liver injury in r ats. Rats (n = 6) received 10% DMSO(negative control), 200 mg/kg silymarin (positive control) or MEDL (50, 250, and 500 mg/kg) orally once daily for 7 days and 3 hours after the last adminis tration of the test solutions, they were subjected to the hepatotoxic induction either using carbon tetrachloride (CCl4) or paracetamol (PCM). The bloods and livers were collected and subjected to biochemical and microscopical analysis. From the data obtained, all doses of MEDL significantly (P < 0.05) reduced the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in CCl4-induced hepatotoxic rats while only the 500 mg/kg MEDL caused significant (P < 0.05) reduction in the level of both enzymes in the PCM-induced liver toxicity model. The histological results obtained were in line with the biochemical analysis. In conclusion, the MEDL-induced hepatoprotective activity is attributed partly to its free radicals scavenging and antioxidant activities and high flav onoids content. Academic Journals 2013-05-17 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/29680/1/Effect%20of%20methanol%20extract%20of%20Dicranopteris%20linearis%20leaves%20against%20paracetamol.pdf Mamat, Siti Syariah and Kamisan, Farah Hidayah and Wan Zainulddin, Wan Noraziemah and Ismail, Noor Aisyah and Yahya, Farhana and Din, Siti Shamsahal and Zabidi, Zalina and Mohtarrudin, Norhafizah and Abd. Kadir, Arifah and Zakaria, Zainul Amiruddin (2013) Effect of methanol extract of Dicranopteris linearis leaves against paracetamol- and carbon tetrachloride (CCl4)-induced liver toxicity in rats. Journal of Medicinal Plants Research, 7 (19). pp. 1305-1309. ISSN 1996-0875 http://www.biomedcentral.com/1472-6882/14/123/abstract 10.5897/JMPR12.630 |
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The present study aimed to determine the hepatoprotective activity of methanol extract of Dicranopteris linearis leaves (MEDL) using two models of liver injury in r
ats. Rats (n = 6) received 10% DMSO(negative control), 200 mg/kg silymarin (positive control) or MEDL (50, 250, and 500 mg/kg) orally once daily for 7 days and 3 hours after the last adminis tration of the test solutions, they were subjected to the hepatotoxic induction either using carbon tetrachloride (CCl4) or paracetamol (PCM). The bloods
and livers were collected and subjected to biochemical and microscopical analysis. From the data obtained, all doses of MEDL significantly (P < 0.05) reduced the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in CCl4-induced hepatotoxic rats while only the 500 mg/kg MEDL caused significant (P < 0.05) reduction in the
level of both enzymes in the PCM-induced liver toxicity model. The histological results obtained were in line with the biochemical analysis. In conclusion, the MEDL-induced hepatoprotective activity is attributed partly to its free radicals scavenging and antioxidant activities and high flav
onoids content. |
format |
Article |
author |
Mamat, Siti Syariah Kamisan, Farah Hidayah Wan Zainulddin, Wan Noraziemah Ismail, Noor Aisyah Yahya, Farhana Din, Siti Shamsahal Zabidi, Zalina Mohtarrudin, Norhafizah Abd. Kadir, Arifah Zakaria, Zainul Amiruddin |
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Mamat, Siti Syariah Kamisan, Farah Hidayah Wan Zainulddin, Wan Noraziemah Ismail, Noor Aisyah Yahya, Farhana Din, Siti Shamsahal Zabidi, Zalina Mohtarrudin, Norhafizah Abd. Kadir, Arifah Zakaria, Zainul Amiruddin Effect of methanol extract of Dicranopteris linearis leaves against paracetamol- and carbon tetrachloride (CCl4)-induced liver toxicity in rats |
author_facet |
Mamat, Siti Syariah Kamisan, Farah Hidayah Wan Zainulddin, Wan Noraziemah Ismail, Noor Aisyah Yahya, Farhana Din, Siti Shamsahal Zabidi, Zalina Mohtarrudin, Norhafizah Abd. Kadir, Arifah Zakaria, Zainul Amiruddin |
author_sort |
Mamat, Siti Syariah |
title |
Effect of methanol extract of Dicranopteris linearis leaves against paracetamol- and carbon tetrachloride (CCl4)-induced liver toxicity in rats |
title_short |
Effect of methanol extract of Dicranopteris linearis leaves against paracetamol- and carbon tetrachloride (CCl4)-induced liver toxicity in rats |
title_full |
Effect of methanol extract of Dicranopteris linearis leaves against paracetamol- and carbon tetrachloride (CCl4)-induced liver toxicity in rats |
title_fullStr |
Effect of methanol extract of Dicranopteris linearis leaves against paracetamol- and carbon tetrachloride (CCl4)-induced liver toxicity in rats |
title_full_unstemmed |
Effect of methanol extract of Dicranopteris linearis leaves against paracetamol- and carbon tetrachloride (CCl4)-induced liver toxicity in rats |
title_sort |
effect of methanol extract of dicranopteris linearis leaves against paracetamol- and carbon tetrachloride (ccl4)-induced liver toxicity in rats |
publisher |
Academic Journals |
publishDate |
2013 |
url |
http://psasir.upm.edu.my/id/eprint/29680/1/Effect%20of%20methanol%20extract%20of%20Dicranopteris%20linearis%20leaves%20against%20paracetamol.pdf http://psasir.upm.edu.my/id/eprint/29680/ http://www.biomedcentral.com/1472-6882/14/123/abstract |
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13.160551 |