Utilization of I-domain of LFA-1 to target drug and marker molecules to Leukocytes.

• Main Authors: Manikwar, Prakash, Tejo, Bimo Ario, Shinogle, Heather, Moore, David S., Zimmerman, Tahl, Blanco, Francisco, Siahaan, Teruna J.
• Format: Article
• Language: English; English
• Published: Ivyspring International Publisher 2011
• Online Access: http://psasir.upm.edu.my/id/eprint/25114/1/Utilization%20of%20I.pdf; http://psasir.upm.edu.my/id/eprint/25114/; http://ivyspring.com/

The long-term objective of this project is to utilize the I-domain protein for the α-subunit of LFA-1 to target drugs to lymphocytes by binding to ICAM receptors on the cell surface. The short-term goal is to provide proof-of-concept that I-domain conjugated to small molecules can still bind to and...