The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin.

• Main Authors: Abdul Manan, Mohd Abdul Fatah, Mohamed Tahir, Mohamed Ibrahim, Crouse, Karen Anne, Rosli, Rozita, How, Fiona Ni Foong, Watkin, David J.
• Format: Article
• Language: English; English
• Published: Springer Verlag 2011
• Online Access: http://psasir.upm.edu.my/id/eprint/25044/1/The%20crystal%20structure%20and%20cytotoxicity%20of%20centrosymmetric%20copper.pdf; http://psasir.upm.edu.my/id/eprint/25044/; http://link.springer.com/

Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB-231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in an orthorhombic crystal system with a space group C 2cb and was found to be selectively active against MCF-7 cell line (Human non-metastatic mammary gland adenocarcinoma cell line with an IC50 value 0.45 μg/mL. The crystal structure of this centrosymmetric Cu(SMISA)2 complex (SMISA = Schiff base formed by condensation reaction of S-methyldithiocarbazate with isatin) showed that the copper atom has a distorted square-planar geometry with the Schiff base coordinated to the metal ion as a uninegatively charged bidentate ligand through the azomethine nitrogen and thiolate sulfur.