New vasorelaxant indole alkaloids, villocarines A-D from Uncaria villosa.

• Main Authors: Matsuo, Hirotaka, Okamoto, Ryuichi, Zaima, Kazumasa, Hirasawa, Yusuke, Ismail, Intan Safinar, Lajis, Md. Nordin, Morita, Hiroshi
• Format: Article
• Language: English; English
• Published: Elsevier 2011
• Online Access: http://psasir.upm.edu.my/id/eprint/24848/1/New%20vasorelaxant%20indole%20alkaloids.pdf; http://psasir.upm.edu.my/id/eprint/24848/; http://www.elsevier.com/

Villocarines A–D (1–4), four new indole alkaloids have been isolated from the leaves of Uncaria villosa (Rubiaceae) and their structures were elucidated by 2D NMR methods and chemical correlations. Villocarine A (1) showed vasorelaxation activity against rat aortic ring and showed inhibition effect...