Parameter estimation of the cure fraction based on BCH model using left-censored data with covariates.
Medical investigations nowadays allow the incorporation of cure individuals in the analysis, especially for chronic diseases such as cancer. Therefore, survival models that incorporate the cured patients in the analysis are called cure rate models. In this paper, we propose an analytical approach fo...
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Canadian Center of Science and Education
2011
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Online Access: | http://psasir.upm.edu.my/id/eprint/24828/1/Parameter%20estimation%20of%20the%20cure%20fraction%20based%20on%20BCH%20model%20using%20left.pdf http://psasir.upm.edu.my/id/eprint/24828/ http://web.ccsenet.org/ |
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my.upm.eprints.248282015-09-23T00:45:45Z http://psasir.upm.edu.my/id/eprint/24828/ Parameter estimation of the cure fraction based on BCH model using left-censored data with covariates. I. Aljawadi, Bader Ahnad Abu Bakar, Mohd Rizam Ibrahim, Noor Akma Midi, Habshah Medical investigations nowadays allow the incorporation of cure individuals in the analysis, especially for chronic diseases such as cancer. Therefore, survival models that incorporate the cured patients in the analysis are called cure rate models. In this paper, we propose an analytical approach for parametric estimation of the cure fraction in cancer clinical trials based on the bounded cumulative hazard (BCH) model with covariates involved in the data set. The analysis is constructed by means of the exponential distribution in the case of left censoring and within the framework of the expectation maximization (EM) algorithm. The analysis provided the analytical solution and a simulation study for the cure rate parameter. Canadian Center of Science and Education 2011-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/24828/1/Parameter%20estimation%20of%20the%20cure%20fraction%20based%20on%20BCH%20model%20using%20left.pdf I. Aljawadi, Bader Ahnad and Abu Bakar, Mohd Rizam and Ibrahim, Noor Akma and Midi, Habshah (2011) Parameter estimation of the cure fraction based on BCH model using left-censored data with covariates. Modern Applied Science, 5 (3). pp. 103-110. ISSN 1913-1852 http://web.ccsenet.org/ 10.5539/mas.v5n3p103 English |
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Medical investigations nowadays allow the incorporation of cure individuals in the analysis, especially for chronic diseases such as cancer. Therefore, survival models that incorporate the cured patients in the analysis are called cure rate models. In this paper, we propose an analytical approach for parametric estimation of the cure fraction in cancer clinical trials based on the bounded cumulative hazard (BCH) model with covariates involved in the data set. The analysis is constructed by means of the exponential distribution in the case of left censoring and within the framework of the expectation maximization (EM) algorithm. The analysis provided the analytical solution and a simulation study for the cure rate parameter.
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Article |
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I. Aljawadi, Bader Ahnad Abu Bakar, Mohd Rizam Ibrahim, Noor Akma Midi, Habshah |
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I. Aljawadi, Bader Ahnad Abu Bakar, Mohd Rizam Ibrahim, Noor Akma Midi, Habshah Parameter estimation of the cure fraction based on BCH model using left-censored data with covariates. |
author_facet |
I. Aljawadi, Bader Ahnad Abu Bakar, Mohd Rizam Ibrahim, Noor Akma Midi, Habshah |
author_sort |
I. Aljawadi, Bader Ahnad |
title |
Parameter estimation of the cure fraction based on BCH model using left-censored data with covariates. |
title_short |
Parameter estimation of the cure fraction based on BCH model using left-censored data with covariates. |
title_full |
Parameter estimation of the cure fraction based on BCH model using left-censored data with covariates. |
title_fullStr |
Parameter estimation of the cure fraction based on BCH model using left-censored data with covariates. |
title_full_unstemmed |
Parameter estimation of the cure fraction based on BCH model using left-censored data with covariates. |
title_sort |
parameter estimation of the cure fraction based on bch model using left-censored data with covariates. |
publisher |
Canadian Center of Science and Education |
publishDate |
2011 |
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http://psasir.upm.edu.my/id/eprint/24828/1/Parameter%20estimation%20of%20the%20cure%20fraction%20based%20on%20BCH%20model%20using%20left.pdf http://psasir.upm.edu.my/id/eprint/24828/ http://web.ccsenet.org/ |
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13.18916 |