Genome-wide gene expression profiling identifies overlap with malignant adrenocortical tumours and novel mechanisms of inefficient steroidogenesis in familial ACTH-independent macronodular adrenal hyperplasia.

• Main Authors: Gagliardi, Lucia, Ling, King Hwa, Chung, Hoow Kok, Carolan, Joseph, Brautigan, Peter, Kenyon, Rosalie, J. D'Andrea, Richard, Van der Hoek, Mark, N. Hahn, Christopher, Torpy, David
• Format: Article
• Language: English; English
• Published: BioScientifica 2012
• Online Access: http://psasir.upm.edu.my/id/eprint/24738/1/Genome.pdf; http://psasir.upm.edu.my/id/eprint/24738/; http://www.bioscientifica.com/

ACTH-independent macronodular adrenal hyperplasia (AIMAH) is a rare cause of sporadic or familial late-onset Cushing's syndrome. It is a cytologically benign disease, of unknown pathogenesis, and characterised by inefficient steroidogenesis, ascribed to differential cellular localisation of ste...