Effects of 3-(2-Hydroxyphenyl)-1-(5-methyl-furan-2-y-l) propenone (HMP) upon signalling pathways of lipopolysaccharide-induced iNOS synthesis in RAW 264.7 cells.

• Main Authors: Choi, Yi Liew, Kok, Wai Lam, Min, Kyu Kim, Harith, Hanis Hazeera, Chau, Ling Tham, Cheah, Yoke Kqueen, Sulaiman, Mohd Roslan, Lajis, Md. Nordin, Israf Ali, Daud Ahmad
• Format: Article
• Language: English; English
• Published: Elsevier 2011
• Online Access: http://psasir.upm.edu.my/id/eprint/24565/1/Effects%20of%203.pdf; http://psasir.upm.edu.my/id/eprint/24565/

NO synthesis in the RAW 264.7 murine macrophage line. The inhibition of NO synthesis was related to inhibition of p38 phosphorylation and kinase activity that led to significant inhibition of phosphorylation of ATF-2. This effect in turn caused inhibition of AP-1-DNA binding which partially explains...