Antinociceptive activity of a synthetic curcuminoid analogue, 2,6-bis-(4-hydroxy-3-methoxybenzylidene)cyclohexanone, on nociception-induced models in mice.

• Main Authors: Lee, Ming Tatt, Khalivulla, Shaik Ibrahim, Akhtar, Muhammad Nadeem, Tengku Mohamad, Tengku Azam Shah, Perimal, Enoch Kumar, Khalid, Mohamed Hanief, Omar Farouk, Ahmad Akira, Lajis, Md. Nordin, Israf Ali, Daud Ahmad, Sulaiman, Mohd Roslan
• Format: Article
• Language: English; English
• Published: Wiley 2012
• Online Access: http://psasir.upm.edu.my/id/eprint/24558/1/Antinociceptive%20activity%20of%20a%20synthetic%20curcuminoid%20analogue.pdf; http://psasir.upm.edu.my/id/eprint/24558/

This study investigated the potential antinociceptive efficacy of a novel synthetic curcuminoid analogue, 2,6-bis-(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC), using chemical- and thermal-induced nociception test models in mice. BHMC (0.03, 0.1, 0.3 and 1.0 mg/kg) administered via intraperit...