Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease.

• Main Authors: Aldhous, Marian C., Abu Bakar @ Jamaludin, Suhaili, Prescott, Natalie J., Palla, Raquel, Soo, Kimberley, Mansfield, John C., Mathew, Christopher G., Satsangi, Jack, Armour, A. L.
• Format: Article
• Language: English; English
• Published: Oxford University Press 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/24407/1/Measurement%20methods%20and%20accuracy%20in%20copy%20number%20variation.pdf; http://psasir.upm.edu.my/id/eprint/24407/; http://hmg.oxfordjournals.org/

The copy number variation in beta-defensin genes on human chromosome 8 has been proposed to underlie susceptibility to inflammatory disorders, but presents considerable challenges for accurate typing on the scale required for adequately powered case-control studies. In this work, we have used accura...