The effects of intramuscular and intraperitoneal injections of benzo(a)pyrene on selected biomarkers in Clarias gariepinus.
This study investigated the dose-dependent and time-course effects of intramuscular (i.m.) and intraperitoneal (i.p.) injection of benzo[a]pyrene (BaP) on the biomarkers EROD activity, GST activity, concentrations of BaP metabolites in bile, and visceral fat deposits (Lipid Somatic Index, LSI) in Af...
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Elsevier
2011
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Online Access: | http://psasir.upm.edu.my/id/eprint/23712/1/The%20effects%20of%20intramuscular%20and%20intraperitoneal%20injections%20of%20benzo.pdf http://psasir.upm.edu.my/id/eprint/23712/ http://www.elsevier.com/ |
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my.upm.eprints.237122015-10-08T00:34:59Z http://psasir.upm.edu.my/id/eprint/23712/ The effects of intramuscular and intraperitoneal injections of benzo(a)pyrene on selected biomarkers in Clarias gariepinus. Varnamkhasti, Ali Karami Christianus, Annie Ishak, Zamri Syed, Mohd Arif Courtenay, Simon Charles This study investigated the dose-dependent and time-course effects of intramuscular (i.m.) and intraperitoneal (i.p.) injection of benzo[a]pyrene (BaP) on the biomarkers EROD activity, GST activity, concentrations of BaP metabolites in bile, and visceral fat deposits (Lipid Somatic Index, LSI) in African catfish (Clarias gariepinus). Intraperitoneal injection resulted in 4.5 times higher accumulation of total selected biliary FACs than i.m. injection. Hepatic GST activities were inhibited by BaP via both injection methods. Dose–response relationships between BaP injection and both biliary FAC concentrations and hepatic GST activities were linear in the i.p. injected group but nonlinear in the i.m. injected fish. Hepatic EROD activity and LSI were not significantly affected by BaP exposure by either injection route. We conclude that i.p. is a more effective route of exposure than i.m. for future ecotoxicological studies of PAH exposure in C. gariepinus. Elsevier 2011 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/23712/1/The%20effects%20of%20intramuscular%20and%20intraperitoneal%20injections%20of%20benzo.pdf Varnamkhasti, Ali Karami and Christianus, Annie and Ishak, Zamri and Syed, Mohd Arif and Courtenay, Simon Charles (2011) The effects of intramuscular and intraperitoneal injections of benzo(a)pyrene on selected biomarkers in Clarias gariepinus. Ecotoxicology and Environmental Safety, 74 (6). pp. 1558-1566. ISSN 0147-6513 http://www.elsevier.com/ 10.1016/j.ecoenv.2011.05.012 |
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This study investigated the dose-dependent and time-course effects of intramuscular (i.m.) and intraperitoneal (i.p.) injection of benzo[a]pyrene (BaP) on the biomarkers EROD activity, GST activity, concentrations of BaP metabolites in bile, and visceral fat deposits (Lipid Somatic Index, LSI) in African catfish (Clarias gariepinus). Intraperitoneal injection resulted in 4.5 times higher accumulation of total selected biliary FACs than i.m. injection. Hepatic GST activities were inhibited by BaP via both injection methods. Dose–response relationships between BaP injection and both biliary FAC concentrations and hepatic GST activities were linear in the i.p. injected group but nonlinear in the i.m. injected fish. Hepatic EROD activity and LSI were not significantly affected by BaP exposure by either injection route. We conclude that i.p. is a more effective route of exposure than i.m. for future ecotoxicological studies of PAH exposure in C. gariepinus. |
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Varnamkhasti, Ali Karami Christianus, Annie Ishak, Zamri Syed, Mohd Arif Courtenay, Simon Charles |
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Varnamkhasti, Ali Karami Christianus, Annie Ishak, Zamri Syed, Mohd Arif Courtenay, Simon Charles The effects of intramuscular and intraperitoneal injections of benzo(a)pyrene on selected biomarkers in Clarias gariepinus. |
author_facet |
Varnamkhasti, Ali Karami Christianus, Annie Ishak, Zamri Syed, Mohd Arif Courtenay, Simon Charles |
author_sort |
Varnamkhasti, Ali Karami |
title |
The effects of intramuscular and intraperitoneal injections of benzo(a)pyrene on selected biomarkers in Clarias gariepinus. |
title_short |
The effects of intramuscular and intraperitoneal injections of benzo(a)pyrene on selected biomarkers in Clarias gariepinus. |
title_full |
The effects of intramuscular and intraperitoneal injections of benzo(a)pyrene on selected biomarkers in Clarias gariepinus. |
title_fullStr |
The effects of intramuscular and intraperitoneal injections of benzo(a)pyrene on selected biomarkers in Clarias gariepinus. |
title_full_unstemmed |
The effects of intramuscular and intraperitoneal injections of benzo(a)pyrene on selected biomarkers in Clarias gariepinus. |
title_sort |
effects of intramuscular and intraperitoneal injections of benzo(a)pyrene on selected biomarkers in clarias gariepinus. |
publisher |
Elsevier |
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2011 |
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http://psasir.upm.edu.my/id/eprint/23712/1/The%20effects%20of%20intramuscular%20and%20intraperitoneal%20injections%20of%20benzo.pdf http://psasir.upm.edu.my/id/eprint/23712/ http://www.elsevier.com/ |
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1643828142193770496 |
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13.188404 |