Safety and clinical usage of Newcastle disease virus in cancer therapy.
Newcastle disease virus (NDV) is an avian virus that causes deadly infection to over 250 species of birds, including domestic and wild-type, thus resulting in substantial losses to the poultry industry worldwide. Many reports have demonstrated the oncolytic effect of NDV towards human tumor cells. T...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Hindawi Publishing Corporation
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/22230/1/Safety%20and%20clinical%20usage%20of%20Newcastle%20disease%20virus%20in%20cancer%20therapy.pdf http://psasir.upm.edu.my/id/eprint/22230/ http://www.hindawi.com/journals/bmri/2011/718710/ |
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| Summary: | Newcastle disease virus (NDV) is an avian virus that causes deadly infection to over 250 species of birds, including domestic and wild-type, thus resulting in substantial losses to the poultry industry worldwide. Many reports have demonstrated the oncolytic effect of NDV towards human tumor cells. The interesting aspect of NDV is its ability to selectively replicate in cancer cells. Some of the studies have undergone human clinical trials, and favorable results were obtained. Therefore, NDV strains can be the
potential therapeutic agent in cancer therapy. However, investigation on the therapeutic perspectives of NDV, specially human immunological effects, is still ongoing. This paper provides an overview of the current studies on the cytotoxic and anticancer effect of NDV via direct oncolysis effects or immune stimulation. Safety of NDV stra
ins applied for cancer immunotherapy is also discussed in this paper. |
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