The therapeutic potential of resistant starch in modulation of insulin resistance, endotoxemia, oxidative stress and antioxidant biomarkers in women with type 2 diabetes: a randomized controlled clinical trial

• Main Authors: Karimi, Pouran, Farhangi, Mahdieh Abbasalizad, Sarmadi, Bahareh, Gargari, Bahram Pourghassem, Javid, Ahmad Zare, Pouraghaei, Mahboob, Dehghan, Parvin
• Format: Article
• Language: English
• Published: Karger 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/17920/1/The%20therapeutic%20potential%20of%20resistant%20starch%20in%20modulation%20of%20insulin%20resistance%2C%20endotoxemia%2C%20oxidative%20stress%20and%20antioxidant%20biomarkers%20in%20women%20with%20type%202%20diabetes%20a%20randomized%20controlled%20clinical%20trial.pdf; http://psasir.upm.edu.my/id/eprint/17920/; http://www.karger.com/Article/Abstract/441683

Aims: This trial aims to determine the effects of resistant starch (RS) subtype 2 (RS2) on glycemic status, metabolic endotoxemia and markers of oxidative stress. Methods: A randomized, controlled, parallel-group clinical trial group of 56 females with type 2 diabetes mellitus (T2DM) was divided to 2 groups. The intervention group (n = 28) and control group (n = 28) received 10 g/day RS2 or placebo for 8 weeks, respectively. Fasting blood samples were taken to determine glycemic status, endotoxin, high sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), total antioxidant capacity (TAC), antioxidant enzymes concentrations as well as uric acid at baseline and after the intervention. Results: After 8 weeks, RS2 caused a significant decrease in the levels of MDA (-34.10%), glycosylated hemoglobin (-9.40%), insulin (-29.36%), homeostasis model of insulin resistance (-32.85%) and endotoxin (-25.00%), a significant increase in TAC (18.10%) and glutathione peroxidase (11.60%) as compared with control. No significant changes were observed in fasting plasma glucose, quantitative insulin sensitivity check index, hs-CRP, superoxide dismutase, catalase and uric acid in the RS2 group as compared with the control group. Conclusion: Supplementation with RS2 may be improved glycemic status, endotoxemia and markers of oxidative stress in patients with T2DM.