Synthesis, characterization and bioactivity of mixed-ligand Cu(II) complexes containing S-methyldithiocarbazate derivatives and saccharinate complex containing S-methyl-β-N-(6-methylpyrid-2-yl)methylenedithiocarbazate
New mixed-ligand complexes of general empirical formula, [Cu(NNS)(sac)(H2O)] (NNS′ = S-methyl-β-N-(6-methylpyrid-2-yl)methylenedithiocarbazate, NNS″ = S-methyl-β-N-(2-acetylpyrid-2-yl)methylenedithiocarbazate and NNS‴ = S-methyl-β-N-(2-benzoylpyrid-2-yl) methylenedithiocarbazate, sac = the saccharin...
Saved in:
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English English |
Published: |
Elsevier
2004
|
Online Access: | http://psasir.upm.edu.my/id/eprint/17745/1/Synthesis.pdf http://psasir.upm.edu.my/id/eprint/17745/ |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.upm.eprints.17745 |
---|---|
record_format |
eprints |
spelling |
my.upm.eprints.177452015-10-29T06:54:45Z http://psasir.upm.edu.my/id/eprint/17745/ Synthesis, characterization and bioactivity of mixed-ligand Cu(II) complexes containing S-methyldithiocarbazate derivatives and saccharinate complex containing S-methyl-β-N-(6-methylpyrid-2-yl)methylenedithiocarbazate Ravoof, Thahira B. S. A. Crouse, Karen Anne Mohamed Tahir, Mohamed Ibrahim Cowley, Andrew R. Ali, Mohammad Akbar New mixed-ligand complexes of general empirical formula, [Cu(NNS)(sac)(H2O)] (NNS′ = S-methyl-β-N-(6-methylpyrid-2-yl)methylenedithiocarbazate, NNS″ = S-methyl-β-N-(2-acetylpyrid-2-yl)methylenedithiocarbazate and NNS‴ = S-methyl-β-N-(2-benzoylpyrid-2-yl) methylenedithiocarbazate, sac = the saccharinate anion) have been synthesized by reacting [Cu(sac)2(H2O)4] · 2H2O with the appropriate ligands in water–ethanol mixtures and characterized by elemental analysis and conductance, magnetic, IR and electronic spectroscopic measurements. Magnetic and spectral evidence support a five-coordinate geometry for the complexes in which the Schiff bases coordinate as NNS tridentate ligands and the saccharinate anion coordinates as a unidentate N-donor ligand. An X-ray crystallographic structural analysis of [Cu(NNS′)(sac)(H2O)] shows that the complex has a distorted square-pyramidal structure in which the Schiff base is coordinated to the copper ion as a tridentate NNS chelating agent via the pyridine nitrogen atom, the azomethine nitrogen atom and the thiolate sulfur atom, the fourth and fifth coordination positions of the five-coordinate Cu(II) ion being occupied by the imino nitrogen of the saccharinate anion and oxygen atom of the aqua ligand. The complexes have been evaluated for their biological activities against eight pathogenic microbials and human T-lymphoblastic leukemia cell lines. The complexes exhibit marked cytotoxicity against leukemic cell lines and display moderate activity against pathogenic bacteria and fungi. Elsevier 2004 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/17745/1/Synthesis.pdf Ravoof, Thahira B. S. A. and Crouse, Karen Anne and Mohamed Tahir, Mohamed Ibrahim and Cowley, Andrew R. and Ali, Mohammad Akbar (2004) Synthesis, characterization and bioactivity of mixed-ligand Cu(II) complexes containing S-methyldithiocarbazate derivatives and saccharinate complex containing S-methyl-β-N-(6-methylpyrid-2-yl)methylenedithiocarbazate. Polyhedron, 23 (16). pp. 2491-2498. ISSN 0277-5387 10.1016/j.poly.2004.08.005 English |
institution |
Universiti Putra Malaysia |
building |
UPM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Putra Malaysia |
content_source |
UPM Institutional Repository |
url_provider |
http://psasir.upm.edu.my/ |
language |
English English |
description |
New mixed-ligand complexes of general empirical formula, [Cu(NNS)(sac)(H2O)] (NNS′ = S-methyl-β-N-(6-methylpyrid-2-yl)methylenedithiocarbazate, NNS″ = S-methyl-β-N-(2-acetylpyrid-2-yl)methylenedithiocarbazate and NNS‴ = S-methyl-β-N-(2-benzoylpyrid-2-yl) methylenedithiocarbazate, sac = the saccharinate anion) have been synthesized by reacting [Cu(sac)2(H2O)4] · 2H2O with the appropriate ligands in water–ethanol mixtures and characterized by elemental analysis and conductance, magnetic, IR and electronic spectroscopic measurements. Magnetic and spectral evidence support a five-coordinate geometry for the complexes in which the Schiff bases coordinate as NNS tridentate ligands and the saccharinate anion coordinates as a unidentate N-donor ligand. An X-ray crystallographic structural analysis of [Cu(NNS′)(sac)(H2O)] shows that the complex has a distorted square-pyramidal structure in which the Schiff base is coordinated to the copper ion as a tridentate NNS chelating agent via the pyridine nitrogen atom, the azomethine nitrogen atom and the thiolate sulfur atom, the fourth and fifth coordination positions of the five-coordinate Cu(II) ion being occupied by the imino nitrogen of the saccharinate anion and oxygen atom of the aqua ligand. The complexes have been evaluated for their biological activities against eight pathogenic microbials and human T-lymphoblastic leukemia cell lines. The complexes exhibit marked cytotoxicity against leukemic cell lines and display moderate activity against pathogenic bacteria and fungi.
|
format |
Article |
author |
Ravoof, Thahira B. S. A. Crouse, Karen Anne Mohamed Tahir, Mohamed Ibrahim Cowley, Andrew R. Ali, Mohammad Akbar |
spellingShingle |
Ravoof, Thahira B. S. A. Crouse, Karen Anne Mohamed Tahir, Mohamed Ibrahim Cowley, Andrew R. Ali, Mohammad Akbar Synthesis, characterization and bioactivity of mixed-ligand Cu(II) complexes containing S-methyldithiocarbazate derivatives and saccharinate complex containing S-methyl-β-N-(6-methylpyrid-2-yl)methylenedithiocarbazate |
author_facet |
Ravoof, Thahira B. S. A. Crouse, Karen Anne Mohamed Tahir, Mohamed Ibrahim Cowley, Andrew R. Ali, Mohammad Akbar |
author_sort |
Ravoof, Thahira B. S. A. |
title |
Synthesis, characterization and bioactivity of mixed-ligand Cu(II) complexes containing S-methyldithiocarbazate derivatives and saccharinate complex containing S-methyl-β-N-(6-methylpyrid-2-yl)methylenedithiocarbazate |
title_short |
Synthesis, characterization and bioactivity of mixed-ligand Cu(II) complexes containing S-methyldithiocarbazate derivatives and saccharinate complex containing S-methyl-β-N-(6-methylpyrid-2-yl)methylenedithiocarbazate |
title_full |
Synthesis, characterization and bioactivity of mixed-ligand Cu(II) complexes containing S-methyldithiocarbazate derivatives and saccharinate complex containing S-methyl-β-N-(6-methylpyrid-2-yl)methylenedithiocarbazate |
title_fullStr |
Synthesis, characterization and bioactivity of mixed-ligand Cu(II) complexes containing S-methyldithiocarbazate derivatives and saccharinate complex containing S-methyl-β-N-(6-methylpyrid-2-yl)methylenedithiocarbazate |
title_full_unstemmed |
Synthesis, characterization and bioactivity of mixed-ligand Cu(II) complexes containing S-methyldithiocarbazate derivatives and saccharinate complex containing S-methyl-β-N-(6-methylpyrid-2-yl)methylenedithiocarbazate |
title_sort |
synthesis, characterization and bioactivity of mixed-ligand cu(ii) complexes containing s-methyldithiocarbazate derivatives and saccharinate complex containing s-methyl-β-n-(6-methylpyrid-2-yl)methylenedithiocarbazate |
publisher |
Elsevier |
publishDate |
2004 |
url |
http://psasir.upm.edu.my/id/eprint/17745/1/Synthesis.pdf http://psasir.upm.edu.my/id/eprint/17745/ |
_version_ |
1643826611631423488 |
score |
13.18916 |