Tissue distribution of intramuscularly and intratumouraly administered DNA plasmid harbouring apoptotic gene in mice

• Main Authors: Ismail, Ruzila, Allaudin, Zeenathul Nazariah, Nik Abd Rahman, Nik Mohd Afizan, Abdul Rahman, Sheikh Omar, Mustafa, Nor Hidayah, Mohd Lila, Mohd Azmi
• Format: Article
• Language: English
• Published: Academic Journals 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/17426/1/Tissue%20distribution%20of%20intramuscularly%20and%20intratumouraly%20administered%20DNA%20plasmid%20harbouring%20apoptotic%20gene%20in%20mice.pdf; http://psasir.upm.edu.my/id/eprint/17426/; https://academicjournals.org/journal/AJPP/article-abstract/3F2106236627

This study investigated the bio-distribution and persistence of plasmid DNA following intramuscular and intratumoural administration in a mice model. Validated quantitative method (real-time qPCR) was used to quantify plasmid distribution in the tissue samples collected at 15 min, 1 h, 24 h and 1 we...