Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation
Curcumin has been found to possess significant pharmaceutical activities. However, owing to its low bioavailability, there is a limitation of employing it towards clinical application. In an attempt to surmount this implication, often the choice is designing novel drug delivery systems. Herein, ster...
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Walter de Gruyter
2016
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Online Access: | http://psasir.upm.edu.my/id/eprint/16275/1/Curcumin-loaded%20sterically%20stabilized%20nanodispersion%20based%20on%20non-ionic%20colloidal%20system%20induced%20by%20ultrasound%20and%20solvent%20diffusion-evaporation.pdf http://psasir.upm.edu.my/id/eprint/16275/ http://www.degruyter.com/view/j/pac.2016.88.issue-1-2/pac-2015-0601/pac-2015-0601.xml |
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my.upm.eprints.162752016-06-08T01:30:19Z http://psasir.upm.edu.my/id/eprint/16275/ Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation Tan, Khang Wei Tang, Siah Ying Thomas, Renjan Neela, Vasantha Kumari Manickam, Sivakumar Curcumin has been found to possess significant pharmaceutical activities. However, owing to its low bioavailability, there is a limitation of employing it towards clinical application. In an attempt to surmount this implication, often the choice is designing novel drug delivery systems. Herein, sterically stabilized nanoscale dispersion loaded with curcumin (nanodispersion) based on non-ionic colloidal system has been proposed. In this study, the process conditions were effectively optimized using response surface methodology (RSM) with Box–Behnken design (BBD). The suggested optimum formulation proved to be an excellent fit to the actual experimental output. STEM images illustrate that the optimal curcumin-loaded nanodispersion has spherical morphology with narrow particle size distribution. Particle size distribution study confirms that the solution pH does not affect the nanodispersion, and physical stability study shows that the colloidal system is stable over 90 days of storage at ambient conditions. More importantly, controlled release profile was achieved over 72 h and the in vitro drug release data fit well to Higuchi model (R2=0.9654). Walter de Gruyter 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/16275/1/Curcumin-loaded%20sterically%20stabilized%20nanodispersion%20based%20on%20non-ionic%20colloidal%20system%20induced%20by%20ultrasound%20and%20solvent%20diffusion-evaporation.pdf Tan, Khang Wei and Tang, Siah Ying and Thomas, Renjan and Neela, Vasantha Kumari and Manickam, Sivakumar (2016) Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation. Pure and Applied Chemistry, 88 (1-2). pp. 43-60. ISSN 0033-4545; ESSN: 1365-3075 http://www.degruyter.com/view/j/pac.2016.88.issue-1-2/pac-2015-0601/pac-2015-0601.xml 10.1515/pac-2015-0601 |
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Curcumin has been found to possess significant pharmaceutical activities. However, owing to its low bioavailability, there is a limitation of employing it towards clinical application. In an attempt to surmount this implication, often the choice is designing novel drug delivery systems. Herein, sterically stabilized nanoscale dispersion loaded with curcumin (nanodispersion) based on non-ionic colloidal system has been proposed. In this study, the process conditions were effectively optimized using response surface methodology (RSM) with Box–Behnken design (BBD). The suggested optimum formulation proved to be an excellent fit to the actual experimental output. STEM images illustrate that the optimal curcumin-loaded nanodispersion has spherical morphology with narrow particle size distribution. Particle size distribution study confirms that the solution pH does not affect the nanodispersion, and physical stability study shows that the colloidal system is stable over 90 days of storage at ambient conditions. More importantly, controlled release profile was achieved over 72 h and the in vitro drug release data fit well to Higuchi model (R2=0.9654). |
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Article |
author |
Tan, Khang Wei Tang, Siah Ying Thomas, Renjan Neela, Vasantha Kumari Manickam, Sivakumar |
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Tan, Khang Wei Tang, Siah Ying Thomas, Renjan Neela, Vasantha Kumari Manickam, Sivakumar Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation |
author_facet |
Tan, Khang Wei Tang, Siah Ying Thomas, Renjan Neela, Vasantha Kumari Manickam, Sivakumar |
author_sort |
Tan, Khang Wei |
title |
Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation |
title_short |
Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation |
title_full |
Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation |
title_fullStr |
Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation |
title_full_unstemmed |
Curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation |
title_sort |
curcumin-loaded sterically stabilized nanodispersion based on non-ionic colloidal system induced by ultrasound and solvent diffusion-evaporation |
publisher |
Walter de Gruyter |
publishDate |
2016 |
url |
http://psasir.upm.edu.my/id/eprint/16275/1/Curcumin-loaded%20sterically%20stabilized%20nanodispersion%20based%20on%20non-ionic%20colloidal%20system%20induced%20by%20ultrasound%20and%20solvent%20diffusion-evaporation.pdf http://psasir.upm.edu.my/id/eprint/16275/ http://www.degruyter.com/view/j/pac.2016.88.issue-1-2/pac-2015-0601/pac-2015-0601.xml |
_version_ |
1643826165641641984 |
score |
13.18916 |