Mutational analysis of CYP2C8 in hypertensive patients using denaturing high performance liquid chromatography.

• Main Authors: Teh, Lay Kek, Zahri, Mohd. Khiari, Zakaria, Zainul Amiruddin, Ismail, Rusli, Salleh, Mohd. Zaki
• Format: Article
• Language: English; English
• Published: Blackwell Publishing Ltd. 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/15767/1/Mutational%20analysis%20of%20CYP2C8%20in%20hypertensive%20patients%20using%20denaturing%20high%20performance%20liquid%20chromatography.pdf; http://psasir.upm.edu.my/id/eprint/15767/; http://www.wiley.com

What is known and Objective: CYP2C8 is involved in the cytochrome P450 (CYP) epoxygenase pathway. Arachidonic acid metabolites such as epoxyeicosatrienenoic acids and hydroxyeicosatetrenoic acids, produced may have a role in hypertension. We aimed to develop a medium through-put method for screeni...