Mitogen-activated protein/extracellular signal-regulated kinase kinase 1act/tubulin interaction is an important determinant of mitotic stability in cultured HT1080 human fibrosarcoma cells.

• Main Authors: Cao, Jia-ning, Shafee, Norazizah, Vickery, Larry, Kaluz, Stefan, Ru, Ning, Stanbridge, Eric J.
• Format: Article
• Language: English; English
• Published: American Association for Cancer Research 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/15646/1/Mitogen.pdf; http://psasir.upm.edu.my/id/eprint/15646/

Activation of the mitogen-activated protein kinase (MAPK) pathway plays a major role in neoplastic cell transformation. Using a proteomics approach, we identified alpha tubulin and beta tubulin as proteins that interact with activated MAP/extracellular signal-regulated kinase kinase 1 (MEK1), a cent...