Analgesic effect of 5-(3,4-dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one in experimental animal models of nociception

• Main Authors: Kamarudin, Nur Nadhirah, Hisamuddin, Nadia, Ong, Hui Ming, Ahmad Azmi, Ahmad Farhan, Leong, Sze Wei, Abas, Faridah, Sulaiman, Mohd Roslan, Shaik Mohamed Mossadeq, Wan Mastura
• Format: Article
• Language: English
• Published: MDPI 2018
• Online Access: http://psasir.upm.edu.my/id/eprint/15344/1/15344.pdf; http://psasir.upm.edu.my/id/eprint/15344/; https://www.mdpi.com/1420-3049/23/9/2099

Curcuminoids derived from turmeric rhizome have been reported to exhibit antinociceptive, antioxidant and anti-inflammatory activities. We evaluated the peripheral and central antinociceptive activities of 5-(3,4-dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one (DHHPD), a novel syn...