Interaction of Hb South Florida (codon 1; GTG→ATG) and HbE, with β-thalassemia (IVS1-1; G→A): expression of different clinical phenotypes

• Main Authors: Tan, Mary Anne Jin Ai, Tan, Kim Lian, Omar, Khairul Zaman, Chan, Lee Lee, Wee, Yong Chui, George, Elizabeth
• Format: Article
• Language: English
• Published: Springer 2009
• Online Access: http://psasir.upm.edu.my/id/eprint/15263/1/Interaction%20of%20Hb%20South%20Florida.pdf; http://psasir.upm.edu.my/id/eprint/15263/

Introduction: Interactions of different hemoglobin variants with thalassemia alleles can result in various clinical phenotypes. HbE-β-thalassemia generally manifests with severe anemia where individuals exhibit β-thalassemia major with regular blood transfusions or β-thalassemia intermedia with per...