In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits.
To study the effects of Tamarindus indica L. aqueous fruit extract on the antinociceptive activities in rodent models. Methods: The analgesic effect was evaluated using acetic acid-induced writhing, hot plate and formalin tests. Results: The extract (60–600 mg/kg) significantly (p < 0.05) inhibit...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Karger: Open Access Journals
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/15172/1/In%20vivo%20analgesic%20effect%20of%20aqueous%20extract%20of%20Tamarindus%20indica%20L.pdf http://psasir.upm.edu.my/id/eprint/15172/ |
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| Summary: | To study the effects of Tamarindus indica L. aqueous fruit extract on the antinociceptive activities in rodent models. Methods: The analgesic effect was evaluated using acetic acid-induced writhing, hot plate and formalin tests. Results: The extract (60–600 mg/kg) significantly (p < 0.05) inhibited the writhing test in a dose-dependent manner with the percentage of analgesia recorded between 51.8 and 74.1%. In addition, the extract also significantly (p < 0.05) increased the latency time in the hot plate test in a dose-dependent manner. Further study showed that the extract elicited inhibitory activity in both the early and late phases of the formalin test. Moreover, pretreatment with 5 mg/kg naloxone, a nonselective opioid receptor antagonist, significantly (p < 0.05) modified the antinociceptive effect of the extract in all tests. Conclusion: The aqueous extract of T. indica possesses potential antinociceptive activity at both the peripheral and central levels, which are mediated via activation of the opioidergic mechanism. |
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