Evaluation of acute toxicity and the effect of single injected doses of zerumbone on the kidney and liver functions in Sprague Dawley rats

• Main Authors: Ibrahim, Mohammed Yousif, Abdul, Ahmad Bustamam, Tengku Ibrahim, Tengku Azmi, Abdelwahab, Siddig Ibrahim, Elhassan Taha, Manal Mohamed, Syam, M. M.
• Format: Article
• Language: English
• Published: Academic Journals 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/14592/1/14952.pdf; http://psasir.upm.edu.my/id/eprint/14592/; http://www.academicjournals.org/journal/AJB/article-abstract/129B99E20507

Zerumbone is a natural monosesquiterpene isolated from the rhizomes of Zingiber zerumbet Smith. This bioactive compound has been previously shown to have chemo-preventive, anti-inflammatory and free radical scavenging activities. This study was designed to determine the median lethal dose (LD 50) of...