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Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum

Four new chromone alkaloids, chrotacumines A-D (1-4), consisting of a 5,7-dihydroxy-2-methylchromone, an N-Me piperidine ring, and an ester side chain were isolated from Dysoxylum acutangulum, and their structures including absolute configurations were elucidated on the basis of spectroscopic data i...

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Main Authors: Ismail, Intan Safinar, Nagakura, Yuta, Hirasawa, Yusuke, Hosoya, Takahiro, Mohd Lazim, Mohd Izwan, Lajis, Md. Nordin, Shiro, Motoo, Morita, Hiroshi
Format: Article
Language:English
Published: American Society of Pharmacognosy & American Chemical Society 2009
Online Access:http://psasir.upm.edu.my/id/eprint/13595/1/Chrotacumines%20A.pdf
http://psasir.upm.edu.my/id/eprint/13595/
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spelling my.upm.eprints.135952015-09-29T02:06:56Z http://psasir.upm.edu.my/id/eprint/13595/ Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum Ismail, Intan Safinar Nagakura, Yuta Hirasawa, Yusuke Hosoya, Takahiro Mohd Lazim, Mohd Izwan Lajis, Md. Nordin Shiro, Motoo Morita, Hiroshi Four new chromone alkaloids, chrotacumines A-D (1-4), consisting of a 5,7-dihydroxy-2-methylchromone, an N-Me piperidine ring, and an ester side chain were isolated from Dysoxylum acutangulum, and their structures including absolute configurations were elucidated on the basis of spectroscopic data interpretation including 2D NMR, CD spectra, and X-ray analysis. The known compound rohitukine (5) showed moderate cytotoxicity against human HL-60 promyelocytic leukemia and HCT-116 colon cancer cells. American Society of Pharmacognosy & American Chemical Society 2009-10 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/13595/1/Chrotacumines%20A.pdf Ismail, Intan Safinar and Nagakura, Yuta and Hirasawa, Yusuke and Hosoya, Takahiro and Mohd Lazim, Mohd Izwan and Lajis, Md. Nordin and Shiro, Motoo and Morita, Hiroshi (2009) Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum. Journal of Natural Products, 72 (10). pp. 1879-1883. ISSN 0163-3864 & Online ISSN: 1520-6025 10.1021/np9003849
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Four new chromone alkaloids, chrotacumines A-D (1-4), consisting of a 5,7-dihydroxy-2-methylchromone, an N-Me piperidine ring, and an ester side chain were isolated from Dysoxylum acutangulum, and their structures including absolute configurations were elucidated on the basis of spectroscopic data interpretation including 2D NMR, CD spectra, and X-ray analysis. The known compound rohitukine (5) showed moderate cytotoxicity against human HL-60 promyelocytic leukemia and HCT-116 colon cancer cells.
format Article
author Ismail, Intan Safinar
Nagakura, Yuta
Hirasawa, Yusuke
Hosoya, Takahiro
Mohd Lazim, Mohd Izwan
Lajis, Md. Nordin
Shiro, Motoo
Morita, Hiroshi
spellingShingle Ismail, Intan Safinar
Nagakura, Yuta
Hirasawa, Yusuke
Hosoya, Takahiro
Mohd Lazim, Mohd Izwan
Lajis, Md. Nordin
Shiro, Motoo
Morita, Hiroshi
Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum
author_facet Ismail, Intan Safinar
Nagakura, Yuta
Hirasawa, Yusuke
Hosoya, Takahiro
Mohd Lazim, Mohd Izwan
Lajis, Md. Nordin
Shiro, Motoo
Morita, Hiroshi
author_sort Ismail, Intan Safinar
title Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum
title_short Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum
title_full Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum
title_fullStr Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum
title_full_unstemmed Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum
title_sort chrotacumines a-d, chromone alkaloids from dysoxylum acutangulum
publisher American Society of Pharmacognosy & American Chemical Society
publishDate 2009
url http://psasir.upm.edu.my/id/eprint/13595/1/Chrotacumines%20A.pdf
http://psasir.upm.edu.my/id/eprint/13595/
_version_ 1643825378544844800
score 13.214268

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