Anti-inflammatory and anti-nociceptive activities of the ethanolic extract of Annona muricata leaf

• Main Authors: Abd Hamid @ Abdul Razak, Roslida, Tay, C. E., Ahmad, Zuraini, Chan, Pit Foong
• Format: Article
• Language: English
• Published: Informatics Publishing Limited and Natural Remedies 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/13148/1/Anti-inflammatory.pdf; http://psasir.upm.edu.my/id/eprint/13148/; http://www.informaticsjournals.com/index.php/jnr/article/view/249

Ethanolic extract of Annona muricata leaf (AML) was used to investigate its anti-inflammatory and antinociceptive activities by using carrageenan - induced oedema model and acetic acid induced writhing test. AML exhibited significant and dose-dependent anti-inflammatory activity at a dose of 10, 30, 100 and 300 mg/kg when administered orally. It is also demonstrated that the intraperitoneal administration of AML at a dose of 30, 100 and 300 mg/kg produced significant inhibition of abdominal constriction induced with 0.6% (v/v) acetic acid in dose dependent manner. These results indicate that AML exhibits significant anti-inflammatory and antinociceptive effects.