Alkaloids from Piper sarmentosum and Piper nigrum

• Main Authors: Ee, Gwendoline Cheng Lian, Lim, Chyi Meei, Lim, Chan Kiang, Rahmani, Mawardi, Shaari, Khozirah, Bong, Joseph Choon Fah
• Format: Article
• Language: English
• Published: Taylor & Francis 2009
• Online Access: http://psasir.upm.edu.my/id/eprint/12986/1/Alkaloids%20from%20Piper%20sarmentosum%20and%20Piper%20nigrum.pdf; http://psasir.upm.edu.my/id/eprint/12986/

Detailed chemical studies on the roots of Piper sarmentosum and Piper nigrum have resulted in several alkaloids. The roots of P. sarmentosum gave a new aromatic compound, 1-nitrosoimino-2,4,5-trimethoxybenzene (1). Piper nigrum roots gave pellitorine (2), (E)-1-[3',4' (methylenedioxy)cinnamoyl]piperidine (3), 2,4-tetradecadienoic acid isobutyl amide (4), piperine (5), sylvamide (6), cepharadione A (7), piperolactam D (8) and paprazine (9). Structural elucidation of these compounds was achieved through NMR and MS techniques. Cytotoxic activity screening of the plant extracts indicated some activity.