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Acutaxylines A and B, two novel triterpenes from Dysoxylum acutangulum

Two novel triterpenes, acutaxylines A (1) and B (2) consisting of a cyclopentenone side chain at C-17 and an oxepan-2-ol, were isolated from the leaves of Dysoxylum acutangulum. The relative stereochemistry of 1 and 2 was determined by NOESY correlations. Acutaxyline B showed moderate cytotoxicity a...

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Main Authors: Ismail, Intan Safinar, Nagakura, Yuta, Hirasawa, Yusuke, Hosoya, Takahiro, Mohd Lazim, Mohd Izwan, Lajis, Md. Nordin, Morita, Hiroshi
Format: Article
Language:English
Published: Pergamon Press 2009
Online Access:http://psasir.upm.edu.my/id/eprint/12927/1/Acutaxylines%20A%20and%20B.pdf
http://psasir.upm.edu.my/id/eprint/12927/
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spelling my.upm.eprints.129272015-09-29T02:57:03Z http://psasir.upm.edu.my/id/eprint/12927/ Acutaxylines A and B, two novel triterpenes from Dysoxylum acutangulum Ismail, Intan Safinar Nagakura, Yuta Hirasawa, Yusuke Hosoya, Takahiro Mohd Lazim, Mohd Izwan Lajis, Md. Nordin Morita, Hiroshi Two novel triterpenes, acutaxylines A (1) and B (2) consisting of a cyclopentenone side chain at C-17 and an oxepan-2-ol, were isolated from the leaves of Dysoxylum acutangulum. The relative stereochemistry of 1 and 2 was determined by NOESY correlations. Acutaxyline B showed moderate cytotoxicity against human blood premyelocytic leukemia cells. Pergamon Press 2009-08-26 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/12927/1/Acutaxylines%20A%20and%20B.pdf Ismail, Intan Safinar and Nagakura, Yuta and Hirasawa, Yusuke and Hosoya, Takahiro and Mohd Lazim, Mohd Izwan and Lajis, Md. Nordin and Morita, Hiroshi (2009) Acutaxylines A and B, two novel triterpenes from Dysoxylum acutangulum. Tetrahedron Letters, 50 (34). pp. 4830-4832. ISSN 0040-4039; ESSN: 1873-3581 10.1016/j.tetlet.2009.05.110
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Two novel triterpenes, acutaxylines A (1) and B (2) consisting of a cyclopentenone side chain at C-17 and an oxepan-2-ol, were isolated from the leaves of Dysoxylum acutangulum. The relative stereochemistry of 1 and 2 was determined by NOESY correlations. Acutaxyline B showed moderate cytotoxicity against human blood premyelocytic leukemia cells.
format Article
author Ismail, Intan Safinar
Nagakura, Yuta
Hirasawa, Yusuke
Hosoya, Takahiro
Mohd Lazim, Mohd Izwan
Lajis, Md. Nordin
Morita, Hiroshi
spellingShingle Ismail, Intan Safinar
Nagakura, Yuta
Hirasawa, Yusuke
Hosoya, Takahiro
Mohd Lazim, Mohd Izwan
Lajis, Md. Nordin
Morita, Hiroshi
Acutaxylines A and B, two novel triterpenes from Dysoxylum acutangulum
author_facet Ismail, Intan Safinar
Nagakura, Yuta
Hirasawa, Yusuke
Hosoya, Takahiro
Mohd Lazim, Mohd Izwan
Lajis, Md. Nordin
Morita, Hiroshi
author_sort Ismail, Intan Safinar
title Acutaxylines A and B, two novel triterpenes from Dysoxylum acutangulum
title_short Acutaxylines A and B, two novel triterpenes from Dysoxylum acutangulum
title_full Acutaxylines A and B, two novel triterpenes from Dysoxylum acutangulum
title_fullStr Acutaxylines A and B, two novel triterpenes from Dysoxylum acutangulum
title_full_unstemmed Acutaxylines A and B, two novel triterpenes from Dysoxylum acutangulum
title_sort acutaxylines a and b, two novel triterpenes from dysoxylum acutangulum
publisher Pergamon Press
publishDate 2009
url http://psasir.upm.edu.my/id/eprint/12927/1/Acutaxylines%20A%20and%20B.pdf
http://psasir.upm.edu.my/id/eprint/12927/
_version_ 1643825176439160832
score 13.214268

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