2-dodecanol (decyl methyl carbinol) inhibits hyphal formation and SIR2 expression in C. albicans

• Main Authors: Lim, Crystale Siew Ying, Wong, Won Fen, Rosli, Rozita, Ng, Kee Peng, Seow, Heng Fong, Chong, Pei Pei
• Format: Article
• Language: English
• Published: Wiley-VCH Verlag GmbH & Co. KGaA 2009
• Online Access: http://psasir.upm.edu.my/id/eprint/12634/1/2.pdf; http://psasir.upm.edu.my/id/eprint/12634/

Candida albicans is capable of undergoing yeast-hypha transition to attain pathogenicity in humans. In this study, we investigated the differential expression of CaSIR2 via quantitative real-time PCR (qPCR), during yeast-hypha transition with and without the presence of 2-dodecanol. SIR2 transcript...