Enzymatic Synthesis of 3-O-Acylbetulinic Acid Derivatives and Prediction of Acylation Using Response Surface Methodology and Artificial Neural Network Analyses

• Main Author: Moghaddam, Mansour Ghaffari
• Format: Thesis
• Language: English; English
• Published: 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/12441/1/FS_2010_26A.pdf; http://psasir.upm.edu.my/id/eprint/12441/

In this study, 3-O-acyl-betulinic acid derivatives were synthesized by the reaction of betulinic acid with various anhydrides using lipase as a biocatalyst in organic solvents. The reaction between betulinic acid and phthalic anhydride was chosen as the model reaction for optimization studies. Th...