Insulinotropic activity of Tinospora crispa extract: effect on β-cell Ca2+ handling

• Main Authors: Noor, Hamdan, Ashcroft, Stephen J. H.
• 格式: Article
• 語言: English
• 出版: Wiley 1998
• 在線閱讀: http://psasir.upm.edu.my/id/eprint/115037/1/115037.pdf; http://psasir.upm.edu.my/id/eprint/115037/; https://onlinelibrary.wiley.com/doi/10.1002/(SICI)1099-1573(199803)12:2%3C98::AID-PTR195%3E3.0.CO;2-F

The mechanism of insulinotropic action of Tinospora crispa was investigated in vitro using an insulin-secreting clonal β-cell line, HIT-T15. The aqueous extract sensitizes the β-cell to extracellular Ca2+ and promotes intracellular Ca2+ accumulation which in turn causes increased insulin release. Th...