Coordination chemistry and biological activity of two tridentate ONS and NNS Schiff bases derived from S-benzyldithiocarbazate

• Main Authors: Tofazzal, M., Tarafder, H., Ali, Manaf A., Saravanan, N.
• Format: Article
• Published: Kluwer Academic Publishers 2000
• Online Access: http://psasir.upm.edu.my/id/eprint/114457/; https://link.springer.com/article/10.1023/A:1007044910814?error=cookies_not_supported&code=bc87005a-4924-4d25-be24-262a7a060f0c

Two tridentate Schiff bases having ONS and NNS donor sequences were prepared by condensing S-benzyldithiocarbazate (NH2NHCSSCH2Ph) (SBDTC) with pyridine-2-carboxaldehyde and salicylaldehyde, respectively. Complexes of these ligands with NiII, ZnII, CrIII, CoII, CuII, and SnII were studied and characterized by elemental analyses and various physico-chemical techniques. NiII, CuII, ZnII and SnII complexes were four-coordinate while the CrIII, SrIII and CoIII complexes were six-coordinate. The ONS Schiff base was moderately active against leukemia, while its zinc, antimony and cobalt complexes were strongly active against leukemic cells with DC50 = 0.35-5.00.