Dimethyloxalylglycine (DMOG) induced hypoxia promoted migratory and invasive properties of HCT116 colon cancer cell line

• Main Authors: Ahmad, Nor Ezleen Qistina, Mohd Yusoff, Amirah Alhusna, Md Hashim, Nur Fariesha, Abdullah, Nurul Akmaryanti, Muhamad Zakuan, Noraina
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2024
• Online Access: http://psasir.upm.edu.my/id/eprint/113614/1/113614.pdf; http://psasir.upm.edu.my/id/eprint/113614/; https://www.ukm.my/jsm/pdf_files/SM-PDF-53-6-2024/9.pdf

Hypoxia, a condition characterised by low oxygen levels, leads to increased production of a protein called hypoxia-inducible factor-1 alpha (HIF-1α) in cancer cells. This protein is involved in driving processes such as vascularization, cytoskeletal reorganisation, and epithelial-to-mesenchymal tran...