Evaluation of in vitro corrosion behavior and biocompatibility of poly[xylitol‐(1,12‐dodecanedioate)](pxdd)‐ha coated porous iron for bone scaffolds applications

• Main Authors: Md Yusop, Abdul Hakim, Wan Ali, Wan Fahmin Faiz, Jamaludin, Farah Hidayah, Szali Januddi, Fatihhi, Sarian, Murni Nazira, Saad, Norazalina, Wong, Tuck‐Whye, Hidayat, Arif, Nur, Hadi
• Format: Article
• Published: John Wiley and Sons 2024
• Online Access: http://psasir.upm.edu.my/id/eprint/112125/; https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/biot.202300464

The present study evaluates the corrosion behavior of poly[xylitol‐(1,12‐dodecanedioate)](PXDD)‐HA coated porous iron (PXDD140/HA‐Fe) and its cell‐material interaction aimed for temporary bone scaffold applications. The physicochemical analyses show that the addition of 20 wt.% HA into the PXDD polymers leads to a higher crystallinity and lower surface roughness. The corrosion assessments of the PXDD140/HA‐Fe evaluated by electrochemical methods and surface chemistry analysis indicate that HA decelerates Fe corrosion due to a lower hydrolysis rate following lower PXDD content and being more crystalline. The cell viability and cell death mode evaluations of the PXDD140/HA‐Fe exhibit favorable biocompatibility as compared to bare Fe and PXDD‐Fe scaffolds owing to HA's bioactive properties. Thus, the PXDD140/HA‐Fe scaffolds possess the potential to be used as a biodegradable bone implant.