Potential utilization of phenolic acid compounds as anti-inflammatory agents through TNF-α Convertase inhibition mechanisms: a network pharmacology, docking, and molecular dynamics approach

• Main Authors: Ekowati, Juni, Tejo, Bimo A., Maulana, Saipul, Kusuma, Wisnu Ananta, Fatriani, Rizka, Ramadhanti, Nabila Sekar, Norhayati, Novianty, Kholis Amalia, Sulistyowaty, Melanny Ika, Zubair, Muhammad Sulaiman, Yamauchi, Takayasu, Hamid, Iwan Sahrial
• Format: Article
• Published: American Chemical Society
• Online Access: http://psasir.upm.edu.my/id/eprint/110490/; https://pubs.acs.org/doi/suppl/10.1021/acsomega.3c06450/suppl_file/ao3c06450_si_001.pdf

Inflammation is a dysregulated immune response characterized by an excessive release of proinflammatory mediators, such as cytokines and prostanoids, leading to tissue damage and various pathological conditions. Natural compounds, notably phenolic acid phytocompounds from plants, have recently garne...